WEKO3
アイテム
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Anti-metastatic efficacy in carbon-ion radiotherapy combined with alpha--GalCer-pulsed dendritic cells
https://repo.qst.go.jp/records/64039
https://repo.qst.go.jp/records/640399a43d249-58e2-4f84-a505-32211a2e040e
Item type | 会議発表用資料 / Presentation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2010-10-01 | |||||
タイトル | ||||||
タイトル | Anti-metastatic efficacy in carbon-ion radiotherapy combined with alpha--GalCer-pulsed dendritic cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Fujita, Hidetoshi
× Fujita, Hidetoshi× Ohkubo, Yu× Iwakawa, Mayumi× Seino, Ken-ichiro× Nakano, Takashi× Imai, Takashi× 藤田 英俊× 大久保 悠× 岩川 眞由美× 清野 研一郎× 中野 隆史× 今井 高志 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose:Our previous research suggested carbon-ion (c-ion) irradiation upregulated immunogenicity in irradiated tumor, underlining the potential clinical application of radioimmunotherapy. The anti-metastatic mechanism of this therapy was examined using in vivo murine model. Methods:Local leg tumors were inoculated with squamous cell carcinoma (NR-S1) in C3H mice, or Lewis lung carcinoma (LLC) in C57BL and NKT knockout mice. Local tumors were irradiated with a single dose of 6 Gy of c-ion. Thirty-six hours after irradiation, alpha-GalCer-pulsed dendritic cells (alpha-GalCer-DCs) were injected into the leg tumor. The effects on lung metastasis were investigated by analysis of S100A8, a marker of lung pre-metastatic phase. Results:Local tumors inoculated with NR-S1 or LLC in the leg were spontaneously spread to lung, and formed several metastatic nodules. Metastatic nodules of NR-S1 were decreased in the mice treated with combination therapy. The expression of S100A8 was reduced only in the combination of c-ion and alpha-GalCer-DCs. Conclusion:Our research suggested a possible mechanism that niche status of distant organ might be regulated by local c-ion irradiated tumor with enhanced immunity. |
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会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 69th Annual Meeting of Japanese Cancer Association | |||||
発表年月日 | ||||||
日付 | 2010-09-24 | |||||
日付タイプ | Issued |