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Anti-metastatic efficacy in carbon-ion radiotherapy combined with alpha--GalCer-pulsed dendritic cells
https://repo.qst.go.jp/records/64039
https://repo.qst.go.jp/records/640399a43d249-58e2-4f84-a505-32211a2e040e
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-10-01 | |||||
| タイトル | ||||||
| タイトル | Anti-metastatic efficacy in carbon-ion radiotherapy combined with alpha--GalCer-pulsed dendritic cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujita, Hidetoshi
× Fujita, Hidetoshi× Ohkubo, Yu× Iwakawa, Mayumi× Seino, Ken-ichiro× Nakano, Takashi× Imai, Takashi× 藤田 英俊× 大久保 悠× 岩川 眞由美× 清野 研一郎× 中野 隆史× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose:Our previous research suggested carbon-ion (c-ion) irradiation upregulated immunogenicity in irradiated tumor, underlining the potential clinical application of radioimmunotherapy. The anti-metastatic mechanism of this therapy was examined using in vivo murine model. Methods:Local leg tumors were inoculated with squamous cell carcinoma (NR-S1) in C3H mice, or Lewis lung carcinoma (LLC) in C57BL and NKT knockout mice. Local tumors were irradiated with a single dose of 6 Gy of c-ion. Thirty-six hours after irradiation, alpha-GalCer-pulsed dendritic cells (alpha-GalCer-DCs) were injected into the leg tumor. The effects on lung metastasis were investigated by analysis of S100A8, a marker of lung pre-metastatic phase. Results:Local tumors inoculated with NR-S1 or LLC in the leg were spontaneously spread to lung, and formed several metastatic nodules. Metastatic nodules of NR-S1 were decreased in the mice treated with combination therapy. The expression of S100A8 was reduced only in the combination of c-ion and alpha-GalCer-DCs. Conclusion:Our research suggested a possible mechanism that niche status of distant organ might be regulated by local c-ion irradiated tumor with enhanced immunity. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 69th Annual Meeting of Japanese Cancer Association | |||||
| 発表年月日 | ||||||
| 日付 | 2010-09-24 | |||||
| 日付タイプ | Issued | |||||
