{"created":"2023-05-15T14:46:40.521742+00:00","id":64039,"links":{},"metadata":{"_buckets":{"deposit":"d1def6c0-64f0-41f4-b00f-f01ea20eae63"},"_deposit":{"created_by":1,"id":"64039","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"64039"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00064039","sets":["10:29"]},"author_link":["631785","631790","631784","631792","631786","631788","631782","631789","631787","631783","631781","631791"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-09-24","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose:Our previous research suggested carbon-ion (c-ion) irradiation upregulated immunogenicity in irradiated tumor, underlining the potential clinical application of radioimmunotherapy. The anti-metastatic mechanism of this therapy was examined using in vivo murine model.\nMethods:Local leg tumors were inoculated with squamous cell carcinoma (NR-S1) in C3H mice, or Lewis lung carcinoma (LLC) in C57BL and NKT knockout mice. Local tumors were irradiated with a single dose of 6 Gy of c-ion. Thirty-six hours after irradiation, alpha-GalCer-pulsed dendritic cells (alpha-GalCer-DCs) were injected into the leg tumor. The effects on lung metastasis were investigated by analysis of S100A8, a marker of lung pre-metastatic phase.\nResults:Local tumors inoculated with NR-S1 or LLC in the leg were spontaneously spread to lung, and formed several metastatic nodules. Metastatic nodules of NR-S1 were decreased in the mice treated with combination therapy. The expression of S100A8 was reduced only in the combination of c-ion and alpha-GalCer-DCs.\nConclusion:Our research suggested a possible mechanism that niche status of distant organ might be regulated by local c-ion irradiated tumor with enhanced immunity.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"69th Annual Meeting of Japanese Cancer Association","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujita, Hidetoshi"}],"nameIdentifiers":[{"nameIdentifier":"631781","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohkubo, Yu"}],"nameIdentifiers":[{"nameIdentifier":"631782","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwakawa, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"631783","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seino, Ken-ichiro"}],"nameIdentifiers":[{"nameIdentifier":"631784","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakano, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"631785","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"631786","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤田 英俊","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631787","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保 悠","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631788","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川 眞由美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631789","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"清野 研一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631790","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中野 隆史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631791","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"631792","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Anti-metastatic efficacy in carbon-ion radiotherapy combined with alpha--GalCer-pulsed dendritic cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Anti-metastatic efficacy in carbon-ion radiotherapy combined with alpha--GalCer-pulsed dendritic cells"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-10-01"},"publish_date":"2010-10-01","publish_status":"0","recid":"64039","relation_version_is_last":true,"title":["Anti-metastatic efficacy in carbon-ion radiotherapy combined with alpha--GalCer-pulsed dendritic cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:16:07.611946+00:00"}