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Quantative analysis of dopaine D2 receptor binding in human brain using PET with a agonist redioligand[11C]MNPA
https://repo.qst.go.jp/records/62639
https://repo.qst.go.jp/records/626396bbd5367-965c-453e-9489-535046ba9fe4
Item type | 会議発表用資料 / Presentation(1) | |||||
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公開日 | 2008-07-22 | |||||
タイトル | ||||||
タイトル | Quantative analysis of dopaine D2 receptor binding in human brain using PET with a agonist redioligand[11C]MNPA | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Otsuka, Tatsui
× Otsuka, Tatsui× Ito, Hiroshi× Takahashi, Hidehiko× Takano, Harumasa× Arakawa, Ryosuke× Okumura, Masaki× Kodaka, Fumitoshi× Miyoshi, Michie× Sekine, Mizuho× Seki, Chie× Suhara, Tetsuya× Halldin, Christer× Farde, Lars× 大塚 達以× 伊藤 浩× 高橋 英彦× 高野 晴成× 荒川 亮介× 奥村 正紀× 小高 文聰× 三好 美智恵× 関根 瑞保× 関 千江× 須原 哲也× ハルディン クリスタ |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Intrroduction:It has been establishied in vitro that dopamine D2 receptor could be classified into two inrweconvertible affinity states to natural agonist dopamine, the high-and low-affinity states.Dopamine D2 receotir binding in vivo has wildly been measured by PET with the use of antagonist radioligands,such as[11C]racloprode,however,the high-ans low-ahhinity states of dopamine D2 receptors can be distinguished by the antagonist radiologands.(R)-2-11CH3O-N-n-propylnorapomorphine([11C]MNPA)has recentaly been devdeloped as a potent new agonist for in vivo imaging of the high-affinity state of dopamine D2 receptors[1]. In presentstudy,the kinetics of[11C]MNPA in the without an arterial input function wewe alos validated. |
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会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Neuroreceptor Mapping 2008 | |||||
発表年月日 | ||||||
日付 | 2008-07-19 | |||||
日付タイプ | Issued |