WEKO3
アイテム
{"_buckets": {"deposit": "2849ddcd-9402-4c7e-883e-81512af5bd3b"}, "_deposit": {"created_by": 1, "id": "54388", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "54388"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00054388", "sets": ["2"]}, "author_link": ["555557", "555560", "555561", "555554", "555556", "555549", "555548", "555552", "555547", "555553", "555555", "555551", "555559", "555558", "555562", "555550"], "item_10003_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "NIRS-M-243", "bibliographicPageEnd": "53", "bibliographicPageStart": "46", "bibliographicVolumeNumber": "2", "bibliographic_titles": [{"bibliographic_title": "NIRS-ETOILE Joint Symposium on Carbon Ion Radiotherapy"}]}]}, "item_10003_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "A trial of carbon ion radiotherapy (C-ion RT) for hepatocellular carcinoma (HCC) was first conducted in April 1995 at the National Institute of Radiological Sciences (NIRS) in Japan. A total of 193 patients with HCC were enrolled in this clinical trial. In the first and second phase I/II clinical trials, dose escalation studies were carried out in incremental steps of 10%, resulting in the confirmation of both the safety and efficacy of short-course regimens of 12, 8, and 4 fractions. Based on the results, a phase II clinical study with fixed fractionation, that is, 52.8 GyE/4 fractions, was performed. A total of 47 patients were treated during this phase II study, which resulted in low toxicity and attained a high local control rate (96%) for 5 years after treatment. The last clinical study was conducted from April 2003 to August 2005, with a more hypofractionated regimen of 2 fractions/2 days, in which 36 patients were safely treated within a dose escalation range from 32.0 GyE to 38.8 GyE. The 2-fraction therapy protocol is continuing under the license of Highly Advanced Medical Technology. There have been no therapy-related deaths and no severe adverse events. We conclude that, because of the low toxicity and high local control rate, C-ion RT is a promising new, radical, and minimally invasive therapeutic option for HCC.", "subitem_description_type": "Abstract"}]}, "item_10003_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "National Institute of Radiological Sciences"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Imada, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "555547", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yasuda, Shigeo"}], "nameIdentifiers": [{"nameIdentifier": "555548", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamada, Shigeru"}], "nameIdentifiers": [{"nameIdentifier": "555549", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shinoto, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "555550", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oonishi, Kazuhiko"}], "nameIdentifiers": [{"nameIdentifier": "555551", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Endo, Satoshi"}], "nameIdentifiers": [{"nameIdentifier": "555552", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamada, Tadashi"}], "nameIdentifiers": [{"nameIdentifier": "555553", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsujii, Hirohiko"}], "nameIdentifiers": [{"nameIdentifier": "555554", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "今田 浩史", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "555555", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "安田 茂雄", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "555556", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "山田 滋", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "555557", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "篠藤 誠", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "555558", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "大西 和彦", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "555559", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "遠藤 悟史", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "555560", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鎌田 正", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "555561", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "辻井 博彦", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "555562", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "conference paper", "resourceuri": "http://purl.org/coar/resource_type/c_5794"}]}, "item_title": "Carbon Ion Radiotherapy for Liver Cancer", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Carbon Ion Radiotherapy for Liver Cancer"}]}, "item_type_id": "10003", "owner": "1", "path": ["2"], "permalink_uri": "https://repo.qst.go.jp/records/54388", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-11-14"}, "publish_date": "2013-11-14", "publish_status": "0", "recid": "54388", "relation": {}, "relation_version_is_last": true, "title": ["Carbon Ion Radiotherapy for Liver Cancer"], "weko_shared_id": -1}
Carbon Ion Radiotherapy for Liver Cancer
https://repo.qst.go.jp/records/54388
https://repo.qst.go.jp/records/54388e9da8f75-0cd3-4b1d-81c3-7feddfb10c90
Item type | 会議発表論文 / Conference Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2013-11-14 | |||||
タイトル | ||||||
タイトル | Carbon Ion Radiotherapy for Liver Cancer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
資源タイプ | conference paper | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Imada, Hiroshi
× Imada, Hiroshi× Yasuda, Shigeo× Yamada, Shigeru× Shinoto, Makoto× Oonishi, Kazuhiko× Endo, Satoshi× Kamada, Tadashi× Tsujii, Hirohiko× 今田 浩史× 安田 茂雄× 山田 滋× 篠藤 誠× 大西 和彦× 遠藤 悟史× 鎌田 正× 辻井 博彦 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A trial of carbon ion radiotherapy (C-ion RT) for hepatocellular carcinoma (HCC) was first conducted in April 1995 at the National Institute of Radiological Sciences (NIRS) in Japan. A total of 193 patients with HCC were enrolled in this clinical trial. In the first and second phase I/II clinical trials, dose escalation studies were carried out in incremental steps of 10%, resulting in the confirmation of both the safety and efficacy of short-course regimens of 12, 8, and 4 fractions. Based on the results, a phase II clinical study with fixed fractionation, that is, 52.8 GyE/4 fractions, was performed. A total of 47 patients were treated during this phase II study, which resulted in low toxicity and attained a high local control rate (96%) for 5 years after treatment. The last clinical study was conducted from April 2003 to August 2005, with a more hypofractionated regimen of 2 fractions/2 days, in which 36 patients were safely treated within a dose escalation range from 32.0 GyE to 38.8 GyE. The 2-fraction therapy protocol is continuing under the license of Highly Advanced Medical Technology. There have been no therapy-related deaths and no severe adverse events. We conclude that, because of the low toxicity and high local control rate, C-ion RT is a promising new, radical, and minimally invasive therapeutic option for HCC. | |||||
書誌情報 |
NIRS-ETOILE Joint Symposium on Carbon Ion Radiotherapy 巻 2, 号 NIRS-M-243, p. 46-53, 発行日 2011-11 |
|||||
出版者 | ||||||
出版者 | National Institute of Radiological Sciences |