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Induced pluripotent stem cells-derived myeloid-derived suppressor cells regulate the CD8 T cell response.
https://repo.qst.go.jp/records/49501
https://repo.qst.go.jp/records/49501aadd04b6-ed5b-4218-881c-1ebfb2439550
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-01-23 | |||||
タイトル | ||||||
タイトル | Induced pluripotent stem cells-derived myeloid-derived suppressor cells regulate the CD8 T cell response. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Joyce, Daniel
× Joyce, Daniel× Fujino, Masayuki× Morita, Miwa× Araki, Ryoko× Fung, John× Qian, Shiguang× Lu, Lina× Xiao-Kang, Li× Araki, Ryoko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Myeloid-derived suppressor cells (MDSCs) are markedly increased in cancer patients and tumor-bearing mice and promote tumor growth and survival by inhibiting host innate and adaptive immunity. In this study, we generated and characterized MDSCs from murine-induced pluripotent stem cells (iPSCs). The iPSCs were co-cultured with OP9 cells, stimulated with GM-CSF, and became morphologically heterologous under co-culturing with hepatic stellate cells. Allogeneic and OVA-specific antigen stimulation demonstrated that iPS-MDSCs have a T-cell regulatory function. Furthermore, a popliteal lymph node assay and autoimmune hepatitis model showed that iPS-MDSCs also regulate immune responsiveness in vivo and have a therapeutic effect against hepatitis. Taken together, our results demonstrated a method of generating functional MDSCs from iPSCs and highlighted the potential of iPS-MDSCs as a key cell therapy resource for transplantation and autoimmune diseases. | |||||
書誌情報 |
Stem cell research 巻 29, p. 32-41, 発行日 2018-03 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1873-5061 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 29574174 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.scr.2018.03.009 |