{"created":"2023-05-15T14:38:21.339352+00:00","id":49501,"links":{},"metadata":{"_buckets":{"deposit":"f7bc8e99-1cd9-442e-8a0e-4ff7febeb3f0"},"_deposit":{"created_by":1,"id":"49501","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"49501"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00049501","sets":["1"]},"author_link":["747315","747312","747314","747320","747319","747318","747316","747317","747313"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"32-41","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"Stem cell research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Myeloid-derived suppressor cells (MDSCs) are markedly increased in cancer patients and tumor-bearing mice and promote tumor growth and survival by inhibiting host innate and adaptive immunity. In this study, we generated and characterized MDSCs from murine-induced pluripotent stem cells (iPSCs). The iPSCs were co-cultured with OP9 cells, stimulated with GM-CSF, and became morphologically heterologous under co-culturing with hepatic stellate cells. Allogeneic and OVA-specific antigen stimulation demonstrated that iPS-MDSCs have a T-cell regulatory function. Furthermore, a popliteal lymph node assay and autoimmune hepatitis model showed that iPS-MDSCs also regulate immune responsiveness in vivo and have a therapeutic effect against hepatitis. Taken together, our results demonstrated a method of generating functional MDSCs from iPSCs and highlighted the potential of iPS-MDSCs as a key cell therapy resource for transplantation and autoimmune diseases.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"29574174","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.scr.2018.03.009","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1873-5061","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Joyce, Daniel"}],"nameIdentifiers":[{"nameIdentifier":"747312","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujino, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"747313","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morita, Miwa"}],"nameIdentifiers":[{"nameIdentifier":"747314","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Araki, Ryoko"}],"nameIdentifiers":[{"nameIdentifier":"747315","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fung, John"}],"nameIdentifiers":[{"nameIdentifier":"747316","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Qian, Shiguang"}],"nameIdentifiers":[{"nameIdentifier":"747317","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lu, Lina"}],"nameIdentifiers":[{"nameIdentifier":"747318","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Xiao-Kang, Li"}],"nameIdentifiers":[{"nameIdentifier":"747319","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Araki, Ryoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"747320","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Induced pluripotent stem cells-derived myeloid-derived suppressor cells regulate the CD8 T cell response.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Induced pluripotent stem cells-derived myeloid-derived suppressor cells regulate the CD8 T cell response."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-01-23"},"publish_date":"2019-01-23","publish_status":"0","recid":"49501","relation_version_is_last":true,"title":["Induced pluripotent stem cells-derived myeloid-derived suppressor cells regulate the CD8 T cell response."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T01:13:00.189614+00:00"}