@article{oai:repo.qst.go.jp:00049501,
 author = {Joyce, Daniel and Fujino, Masayuki and Morita, Miwa and Araki, Ryoko and Fung, John and Qian, Shiguang and Lu, Lina and Xiao-Kang, Li and Araki, Ryoko},
 journal = {Stem cell research},
 month = {Mar},
 note = {Myeloid-derived suppressor cells (MDSCs) are markedly increased in cancer patients and tumor-bearing mice and promote tumor growth and survival by inhibiting host innate and adaptive immunity. In this study, we generated and characterized MDSCs from murine-induced pluripotent stem cells (iPSCs). The iPSCs were co-cultured with OP9 cells, stimulated with GM-CSF, and became morphologically heterologous under co-culturing with hepatic stellate cells. Allogeneic and OVA-specific antigen stimulation demonstrated that iPS-MDSCs have a T-cell regulatory function. Furthermore, a popliteal lymph node assay and autoimmune hepatitis model showed that iPS-MDSCs also regulate immune responsiveness in vivo and have a therapeutic effect against hepatitis. Taken together, our results demonstrated a method of generating functional MDSCs from iPSCs and highlighted the potential of iPS-MDSCs as a key cell therapy resource for transplantation and autoimmune diseases.},
 title = {Induced pluripotent stem cells-derived myeloid-derived suppressor cells regulate the CD8 T cell response.},
 volume = {29},
 year = {2018}
}