WEKO3
アイテム
{"_buckets": {"deposit": "92cc0781-04e9-471e-ba95-a83751424978"}, "_deposit": {"created_by": 1, "id": "48620", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "48620"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00048620", "sets": ["1"]}, "author_link": ["488936", "488943", "488949", "488942", "488955", "488944", "488934", "488937", "488950", "488945", "488948", "488935", "488933", "488932", "488953", "488947", "488938", "488941", "488939", "488940", "488951", "488952", "488946", "488954"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "465", "bibliographicPageStart": "455", "bibliographicVolumeNumber": "21", "bibliographic_titles": [{"bibliographic_title": "Cell Reports"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Chromatin remodeling is required for genome function and is facilitated by ATP-dependent complexes, such as nucleosome remodeling and deacetylase (NuRD). Among its core components is the chromodomain helicase DNA binding protein 3 (CHD3) whose functional significance is not well established. Here, we show that CHD3 co-localizes with the other NuRD subunits, including HDAC1, near the H3K9ac-enriched promoters of the NuRD target genes. The tandem PHD fingers of CHD3 bind histone H3 tails and posttranslational modifications that increase hydrophobicity of H3K9-methylation or acetylation (H3K9me3 or H3K9ac)-enhance this interaction. Binding of CHD3 PHDs promotes H3K9Cme3-nucleosome unwrapping in vitro and perturbs the pericentric heterochromatin structure in vivo. Methylation or acetylation of H3K9 uniquely alleviates the intra-nucleosomal interaction of histone H3 tails, increasing H3K9 accessibility. Collectively, our data suggest that the targeting of covalently modified H3K9 by CHD3 might be essential in diverse functions of NuRD.", "subitem_description_type": "Abstract"}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "29020631", "subitem_relation_type_select": "PMID"}}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.celrep.2017.09.054", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://www.ncbi.nlm.nih.gov/pubmed/29020631"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.ncbi.nlm.nih.gov/pubmed/29020631", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2211-1247", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "A., H. Tencer"}], "nameIdentifiers": [{"nameIdentifier": "488932", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "K.L., Cox"}], "nameIdentifiers": [{"nameIdentifier": "488933", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "D., Luo"}], "nameIdentifiers": [{"nameIdentifier": "488934", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "J., B. Bridgers"}], "nameIdentifiers": [{"nameIdentifier": "488935", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "J, Lyu"}], "nameIdentifiers": [{"nameIdentifier": "488936", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "X., Wang"}], "nameIdentifiers": [{"nameIdentifier": "488937", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "J., K. Sims"}], "nameIdentifiers": [{"nameIdentifier": "488938", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "T.M., Weaver"}], "nameIdentifiers": [{"nameIdentifier": "488939", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "H., F. Allen"}], "nameIdentifiers": [{"nameIdentifier": "488940", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Y., Zhang"}], "nameIdentifiers": [{"nameIdentifier": "488941", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "J., Gatchalian"}], "nameIdentifiers": [{"nameIdentifier": "488942", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "M., Darcy"}], "nameIdentifiers": [{"nameIdentifier": "488943", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "M., Gibson"}], "nameIdentifiers": [{"nameIdentifier": "488944", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "J., Ikebe"}], "nameIdentifiers": [{"nameIdentifier": "488945", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "W., Li"}], "nameIdentifiers": [{"nameIdentifier": "488946", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "P.A., Wade"}], "nameIdentifiers": [{"nameIdentifier": "488947", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "J.J., Hayes"}], "nameIdentifiers": [{"nameIdentifier": "488948", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "B., D. Strahl"}], "nameIdentifiers": [{"nameIdentifier": "488949", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "H., Kono"}], "nameIdentifiers": [{"nameIdentifier": "488950", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "M, .G. Poirier"}], "nameIdentifiers": [{"nameIdentifier": "488951", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "C., A. Musselman"}], "nameIdentifiers": [{"nameIdentifier": "488952", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "T., G. Kutateladze"}], "nameIdentifiers": [{"nameIdentifier": "488953", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ルオ ディ", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "488954", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "河野 秀俊", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "488955", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Covalent modifications of histone H3K9 promote binding of CHD3", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Covalent modifications of histone H3K9 promote binding of CHD3"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/48620", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-03-23"}, "publish_date": "2018-03-23", "publish_status": "0", "recid": "48620", "relation": {}, "relation_version_is_last": true, "title": ["Covalent modifications of histone H3K9 promote binding of CHD3"], "weko_shared_id": -1}
Covalent modifications of histone H3K9 promote binding of CHD3
https://repo.qst.go.jp/records/48620
https://repo.qst.go.jp/records/48620e9a0c0db-2620-4e21-b218-40ad21f51c07
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2018-03-23 | |||||
タイトル | ||||||
タイトル | Covalent modifications of histone H3K9 promote binding of CHD3 | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
A., H. Tencer
× A., H. Tencer× K.L., Cox× D., Luo× J., B. Bridgers× J, Lyu× X., Wang× J., K. Sims× T.M., Weaver× H., F. Allen× Y., Zhang× J., Gatchalian× M., Darcy× M., Gibson× J., Ikebe× W., Li× P.A., Wade× J.J., Hayes× B., D. Strahl× H., Kono× M, .G. Poirier× C., A. Musselman× T., G. Kutateladze× ルオ ディ× 河野 秀俊 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Chromatin remodeling is required for genome function and is facilitated by ATP-dependent complexes, such as nucleosome remodeling and deacetylase (NuRD). Among its core components is the chromodomain helicase DNA binding protein 3 (CHD3) whose functional significance is not well established. Here, we show that CHD3 co-localizes with the other NuRD subunits, including HDAC1, near the H3K9ac-enriched promoters of the NuRD target genes. The tandem PHD fingers of CHD3 bind histone H3 tails and posttranslational modifications that increase hydrophobicity of H3K9-methylation or acetylation (H3K9me3 or H3K9ac)-enhance this interaction. Binding of CHD3 PHDs promotes H3K9Cme3-nucleosome unwrapping in vitro and perturbs the pericentric heterochromatin structure in vivo. Methylation or acetylation of H3K9 uniquely alleviates the intra-nucleosomal interaction of histone H3 tails, increasing H3K9 accessibility. Collectively, our data suggest that the targeting of covalently modified H3K9 by CHD3 might be essential in diverse functions of NuRD. | |||||
書誌情報 |
Cell Reports 巻 21, 号 2, p. 455-465, 発行日 2017-10 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2211-1247 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 29020631 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.celrep.2017.09.054 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.ncbi.nlm.nih.gov/pubmed/29020631 | |||||
関連名称 | https://www.ncbi.nlm.nih.gov/pubmed/29020631 |