WEKO3
アイテム
{"_buckets": {"deposit": "f3a5b6e2-ebfe-438b-86e7-7c5649d7b48d"}, "_deposit": {"created_by": 1, "id": "48209", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "48209"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00048209", "sets": ["1"]}, "author_link": ["484315", "484322", "484320", "484319", "484323", "484321", "484326", "484318", "484325", "484316", "484317", "484324"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageEnd": "4606", "bibliographicPageStart": "4601", "bibliographicVolumeNumber": "36", "bibliographic_titles": [{"bibliographic_title": "Anticancer Research"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background: Nano-scale drug delivery systems (nano-DDS) are under active investigation. Nano-platforms are developed for specific administration of small molecules, drugs, genes, contrast agents [quantum dots (QDs] both in vivo and in vitro. Electroporation is a biophysical phenomenon which consists of the application of external electrical pulses across the cell membrane. The aim of this study was to research electro-assisted Colon 26 cell line internalization of QDs and QD-loaded nano-hydrogels (polymersomes) visualized by confocal microscopy and their influence on cell viability. Materials and Methods: The experiments were performed on the Colon 26 cancer cell line, using a confocal fluorescent imaging system and cell viability test. Results: Electroporation facilitated the delivery of nanoparticles in vivo. We demonstrated increased voltagedependent delivery of nanoparticles into cells after electrotreatment, without significant cell viability reduction. Conclusion: The delivery and retention of the polymersomes in vitro is a promising tool for future cancer treatment strategies and nanomedcine.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "International Institute of Anticancer Research (IIAR)"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.21873/anticanres.11009", "subitem_relation_type_select": "DOI"}}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Atanasova, Severina"}], "nameIdentifiers": [{"nameIdentifier": "484315", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nikolova, Biliana"}], "nameIdentifiers": [{"nameIdentifier": "484316", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murayama, Shuhei"}], "nameIdentifiers": [{"nameIdentifier": "484317", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Stoyanova, Elena"}], "nameIdentifiers": [{"nameIdentifier": "484318", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsoneva, Iana"}], "nameIdentifiers": [{"nameIdentifier": "484319", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhelev, Zhivko"}], "nameIdentifiers": [{"nameIdentifier": "484320", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aoki, Ichio"}], "nameIdentifiers": [{"nameIdentifier": "484321", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Bakalova, Rumiana"}], "nameIdentifiers": [{"nameIdentifier": "484322", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "村山 周平", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "484323", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhelev Zhivko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "484324", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "青木 伊知男", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "484325", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "バカロバ ルミアナ", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "484326", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Electroinduced Delivery of Hydrogel Nanoparticles in Colon 26 Cells, Visualized by Confocal Fluorescence System", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Electroinduced Delivery of Hydrogel Nanoparticles in Colon 26 Cells, Visualized by Confocal Fluorescence System"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/48209", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-07-26"}, "publish_date": "2017-07-26", "publish_status": "0", "recid": "48209", "relation": {}, "relation_version_is_last": true, "title": ["Electroinduced Delivery of Hydrogel Nanoparticles in Colon 26 Cells, Visualized by Confocal Fluorescence System"], "weko_shared_id": -1}
Electroinduced Delivery of Hydrogel Nanoparticles in Colon 26 Cells, Visualized by Confocal Fluorescence System
https://repo.qst.go.jp/records/48209
https://repo.qst.go.jp/records/4820901877448-ed1e-41ab-b6a6-4ee323543f9c
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-07-26 | |||||
タイトル | ||||||
タイトル | Electroinduced Delivery of Hydrogel Nanoparticles in Colon 26 Cells, Visualized by Confocal Fluorescence System | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Atanasova, Severina
× Atanasova, Severina× Nikolova, Biliana× Murayama, Shuhei× Stoyanova, Elena× Tsoneva, Iana× Zhelev, Zhivko× Aoki, Ichio× Bakalova, Rumiana× 村山 周平× Zhelev Zhivko× 青木 伊知男× バカロバ ルミアナ |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Nano-scale drug delivery systems (nano-DDS) are under active investigation. Nano-platforms are developed for specific administration of small molecules, drugs, genes, contrast agents [quantum dots (QDs] both in vivo and in vitro. Electroporation is a biophysical phenomenon which consists of the application of external electrical pulses across the cell membrane. The aim of this study was to research electro-assisted Colon 26 cell line internalization of QDs and QD-loaded nano-hydrogels (polymersomes) visualized by confocal microscopy and their influence on cell viability. Materials and Methods: The experiments were performed on the Colon 26 cancer cell line, using a confocal fluorescent imaging system and cell viability test. Results: Electroporation facilitated the delivery of nanoparticles in vivo. We demonstrated increased voltagedependent delivery of nanoparticles into cells after electrotreatment, without significant cell viability reduction. Conclusion: The delivery and retention of the polymersomes in vitro is a promising tool for future cancer treatment strategies and nanomedcine. | |||||
書誌情報 |
Anticancer Research 巻 36, 号 9, p. 4601-4606, 発行日 2016-09 |
|||||
出版者 | ||||||
出版者 | International Institute of Anticancer Research (IIAR) | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.21873/anticanres.11009 |