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Haplotype-based analysis of genes associated with risk of adverse skin reactions after radiotherapy in breast cancer patients.
https://repo.qst.go.jp/records/47665
https://repo.qst.go.jp/records/47665488ffae3-f167-423d-850c-b43969049fa7
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-03-15 | |||||
| タイトル | ||||||
| タイトル | Haplotype-based analysis of genes associated with risk of adverse skin reactions after radiotherapy in breast cancer patients. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Suga, Tomo
× Suga, Tomo× Ishikawa, Atsuko× Kohda, Masakazu× Otsuka, Yoshimi× Yamada, Shigeru× Yamamoto, Naohito× Shibamoto, Yuta× Ogawa, Yoshihiro× Nomura, Kuninori× Sho, Keizen× Omura, Motoko× Sekiguchi, Kenji× Kikuchi, Yuzou× Michikawa, Yuichi× Noda, Shuhei× Sagara, Masashi× Ohashi, Jun× Yoshinaga, Shinji× Mizoe, Junetsu× Tsujii, Hirohiko× Iwakawa, Mayumi× Imai, Takashi× 菅 智× 石川 敦子× 神田 将和× 荘司 好美× 山田 滋× 山本 尚人× 芝本 雄太× 小川 芳弘× 野村 邦紀× 邵 啓全× 大村 素子× 関口 建次× 菊池 雄三× 道川 祐市× 野田 秀平× 相良 雅史× 大橋 順× 吉永 信治× 溝江 純悦× 辻井 博彦× 岩川 眞由美× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | PURPOSE: To identify haplotypes of single nucleotide polymorphism markers associated with the risk of early adverse skin reactions (EASRs) after radiotherapy in breast cancer patients. METHODS AND MATERIALS: DNA was sampled from 399 Japanese breast cancer patients who qualified for breast-conserving radiotherapy. Using the National Cancer Institute-Common Toxicity Criteria scoring system, version 2, the patients were grouped according to EASRs, defined as those occurring within 3 months of starting radiotherapy (Grade 1 or less, n = 290; Grade 2 or greater, n = 109). A total of 999 single nucleotide polymorphisms from 137 candidate genes for radiation susceptibility were genotyped, and the haplotype associations between groups were assessed. RESULTS: The global haplotype association analysis (p < 0.05 and false discovery rate < 0.05) indicated that estimated haplotypes in six loci were associated with EASR risk. A comparison of the risk haplotype with the most frequent haplotype in each locus showed haplotype GGTT in CD44 (odds ratio [OR] = 2.17; 95% confidence interval [CI], 1.07-4.43) resulted in a significantly greater EASR risk. Five haplotypes, CG in MAD2L2 (OR = 0.55; 95% CI, 0.35-0.87), GTTG in PTTG1 (OR = 0.48; 95% CI, 0.24-0.96), TCC (OR = 0.48; 95% CI, 0.26-0.89) and CCG (OR = 0.50; 95% CI, 0.27-0.92) in RAD9A, and GCT in LIG3 (OR = 0.46; 95% CI, 0.22-0.93) were associated with a reduced EASR risk. No significant risk haplotype was observed in REV3L. CONCLUSION: Individual radiosensitivity can be partly determined by these haplotypes in multiple loci. Our findings may lead to a better understanding of the mechanisms underlying the genetic variation in radiation sensitivity and resistance among breast cancer patients. | |||||
| 書誌情報 |
International Journal of Radiation Oncology Biology Physics 巻 69, 号 3, p. 685-693, 発行日 2007-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0360-3016 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.ijrobp.2007.06.021 | |||||
