{"created":"2023-05-15T14:36:59.257155+00:00","id":47665,"links":{},"metadata":{"_buckets":{"deposit":"516b50a6-fda7-4a8b-9336-24166bef7712"},"_deposit":{"created_by":1,"id":"47665","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47665"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047665","sets":["1"]},"author_link":["478180","478173","478179","478175","478213","478188","478184","478200","478202","478187","478212","478178","478199","478192","478181","478171","478198","478214","478191","478201","478183","478197","478189","478176","478203","478211","478174","478177","478190","478193","478206","478209","478172","478194","478204","478205","478196","478207","478195","478210","478186","478182","478208","478185"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"693","bibliographicPageStart":"685","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"International Journal of Radiation Oncology Biology Physics"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PURPOSE: To identify haplotypes of single nucleotide polymorphism markers associated with the risk of early adverse skin reactions (EASRs) after radiotherapy in breast cancer patients. METHODS AND MATERIALS: DNA was sampled from 399 Japanese breast cancer patients who qualified for breast-conserving radiotherapy. Using the National Cancer Institute-Common Toxicity Criteria scoring system, version 2, the patients were grouped according to EASRs, defined as those occurring within 3 months of starting radiotherapy (Grade 1 or less, n = 290; Grade 2 or greater, n = 109). A total of 999 single nucleotide polymorphisms from 137 candidate genes for radiation susceptibility were genotyped, and the haplotype associations between groups were assessed. RESULTS: The global haplotype association analysis (p < 0.05 and false discovery rate < 0.05) indicated that estimated haplotypes in six loci were associated with EASR risk. A comparison of the risk haplotype with the most frequent haplotype in each locus showed haplotype GGTT in CD44 (odds ratio [OR] = 2.17; 95% confidence interval [CI], 1.07-4.43) resulted in a significantly greater EASR risk. Five haplotypes, CG in MAD2L2 (OR = 0.55; 95% CI, 0.35-0.87), GTTG in PTTG1 (OR = 0.48; 95% CI, 0.24-0.96), TCC (OR = 0.48; 95% CI, 0.26-0.89) and CCG (OR = 0.50; 95% CI, 0.27-0.92) in RAD9A, and GCT in LIG3 (OR = 0.46; 95% CI, 0.22-0.93) were associated with a reduced EASR risk. No significant risk haplotype was observed in REV3L. CONCLUSION: Individual radiosensitivity can be partly determined by these haplotypes in multiple loci. Our findings may lead to a better understanding of the mechanisms underlying the genetic variation in radiation sensitivity and resistance among breast cancer patients.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ijrobp.2007.06.021","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0360-3016","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suga, Tomo"}],"nameIdentifiers":[{"nameIdentifier":"478171","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, Atsuko"}],"nameIdentifiers":[{"nameIdentifier":"478172","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kohda, Masakazu"}],"nameIdentifiers":[{"nameIdentifier":"478173","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Otsuka, Yoshimi"}],"nameIdentifiers":[{"nameIdentifier":"478174","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Shigeru"}],"nameIdentifiers":[{"nameIdentifier":"478175","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Naohito"}],"nameIdentifiers":[{"nameIdentifier":"478176","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibamoto, Yuta"}],"nameIdentifiers":[{"nameIdentifier":"478177","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, Yoshihiro"}],"nameIdentifiers":[{"nameIdentifier":"478178","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nomura, Kuninori"}],"nameIdentifiers":[{"nameIdentifier":"478179","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sho, Keizen"}],"nameIdentifiers":[{"nameIdentifier":"478180","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Omura, Motoko"}],"nameIdentifiers":[{"nameIdentifier":"478181","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sekiguchi, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"478182","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kikuchi, Yuzou"}],"nameIdentifiers":[{"nameIdentifier":"478183","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Michikawa, Yuichi"}],"nameIdentifiers":[{"nameIdentifier":"478184","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noda, Shuhei"}],"nameIdentifiers":[{"nameIdentifier":"478185","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sagara, Masashi"}],"nameIdentifiers":[{"nameIdentifier":"478186","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohashi, Jun"}],"nameIdentifiers":[{"nameIdentifier":"478187","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshinaga, Shinji"}],"nameIdentifiers":[{"nameIdentifier":"478188","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizoe, Junetsu"}],"nameIdentifiers":[{"nameIdentifier":"478189","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujii, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"478190","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwakawa, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"478191","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"478192","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅 智","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478193","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川 敦子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478194","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"神田 将和","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478195","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荘司 好美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478196","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 滋","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478197","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本 尚人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478198","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"芝本 雄太","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478199","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川 芳弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478200","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野村 邦紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478201","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"邵 啓全","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478202","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大村 素子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478203","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関口 建次","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478204","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菊池 雄三","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478205","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"道川 祐市","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478206","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野田 秀平","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478207","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"相良 雅史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478208","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大橋 順","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478209","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉永 信治","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478210","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"溝江 純悦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478211","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478212","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川 眞由美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478213","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478214","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Haplotype-based analysis of genes associated with risk of adverse skin reactions after radiotherapy in breast cancer patients.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Haplotype-based analysis of genes associated with risk of adverse skin reactions after radiotherapy in breast cancer patients."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-03-15"},"publish_date":"2017-03-15","publish_status":"0","recid":"47665","relation_version_is_last":true,"title":["Haplotype-based analysis of genes associated with risk of adverse skin reactions after radiotherapy in breast cancer patients."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:36:58.486510+00:00"}