@article{oai:repo.qst.go.jp:00047665,
 author = {Suga, Tomo and Ishikawa, Atsuko and Kohda, Masakazu and Otsuka, Yoshimi and Yamada, Shigeru and Yamamoto, Naohito and Shibamoto, Yuta and Ogawa, Yoshihiro and Nomura, Kuninori and Sho, Keizen and Omura, Motoko and Sekiguchi, Kenji and Kikuchi, Yuzou and Michikawa, Yuichi and Noda, Shuhei and Sagara, Masashi and Ohashi, Jun and Yoshinaga, Shinji and Mizoe, Junetsu and Tsujii, Hirohiko and Iwakawa, Mayumi and Imai, Takashi and 菅 智 and 石川 敦子 and 神田 将和 and 荘司 好美 and 山田 滋 and 山本 尚人 and 芝本 雄太 and 小川 芳弘 and 野村 邦紀 and 邵 啓全 and 大村 素子 and 関口 建次 and 菊池 雄三 and 道川 祐市 and 野田 秀平 and 相良 雅史 and 大橋 順 and 吉永 信治 and 溝江 純悦 and 辻井 博彦 and 岩川 眞由美 and 今井 高志},
 issue = {3},
 journal = {International Journal of Radiation Oncology Biology Physics},
 month = {Sep},
 note = {PURPOSE: To identify haplotypes of single nucleotide polymorphism markers associated with the risk of early adverse skin reactions (EASRs) after radiotherapy in breast cancer patients. METHODS AND MATERIALS: DNA was sampled from 399 Japanese breast cancer patients who qualified for breast-conserving radiotherapy. Using the National Cancer Institute-Common Toxicity Criteria scoring system, version 2, the patients were grouped according to EASRs, defined as those occurring within 3 months of starting radiotherapy (Grade 1 or less, n = 290; Grade 2 or greater, n = 109). A total of 999 single nucleotide polymorphisms from 137 candidate genes for radiation susceptibility were genotyped, and the haplotype associations between groups were assessed. RESULTS: The global haplotype association analysis (p < 0.05 and false discovery rate < 0.05) indicated that estimated haplotypes in six loci were associated with EASR risk. A comparison of the risk haplotype with the most frequent haplotype in each locus showed haplotype GGTT in CD44 (odds ratio [OR] = 2.17; 95% confidence interval [CI], 1.07-4.43) resulted in a significantly greater EASR risk. Five haplotypes, CG in MAD2L2 (OR = 0.55; 95% CI, 0.35-0.87), GTTG in PTTG1 (OR = 0.48; 95% CI, 0.24-0.96), TCC (OR = 0.48; 95% CI, 0.26-0.89) and CCG (OR = 0.50; 95% CI, 0.27-0.92) in RAD9A, and GCT in LIG3 (OR = 0.46; 95% CI, 0.22-0.93) were associated with a reduced EASR risk. No significant risk haplotype was observed in REV3L. CONCLUSION: Individual radiosensitivity can be partly determined by these haplotypes in multiple loci. Our findings may lead to a better understanding of the mechanisms underlying the genetic variation in radiation sensitivity and resistance among breast cancer patients.},
 pages = {685--693},
 title = {Haplotype-based analysis of genes associated with risk of adverse skin reactions after radiotherapy in breast cancer patients.},
 volume = {69},
 year = {2007}
}