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Visualization of complex DNA double-strand breaks in a tumor treated with carbon ion radiotherapy.
https://repo.qst.go.jp/records/47655
https://repo.qst.go.jp/records/47655b515365d-80b4-4cfd-b55b-76f54e393846
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-03-14 | |||||
| タイトル | ||||||
| タイトル | Visualization of complex DNA double-strand breaks in a tumor treated with carbon ion radiotherapy. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Oike, Takahiro
× Oike, Takahiro× Niimi, Atsuko× Okonogi, Noriyuki× Murata, Kazutoshi× Matsumura, Akihiko× Noda, Shin-Ei× Kobayashi, Daijiro× Iwanaga, Mototaro× Tsuchida, Keisuke× Kanai, Tatsuaki× Ohno, Tatsuya× Shibata, Atsushi× Nakano, Takashi× 小此木 範之× 小林 大二郎× 大野 達也× 中野 隆史 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Carbon ion radiotherapy shows great potential as a cure for X-ray-resistant tumors. Basic research suggests that the strong cell-killing effect induced by carbon ions is based on their ability to cause complex DNA double-strand breaks (DSBs). However, evidence supporting the formation of complex DSBs in actual patients is lacking. Here, we used advanced high-resolution microscopy with deconvolution to show that complex DSBs are formed in a human tumor clinically treated with carbon ion radiotherapy, but not in a tumor treated with X-ray radiotherapy. Furthermore, analysis using a physics model suggested that the complexity of radiotherapy-induced DSBs is related to linear energy transfer, which is much higher for carbon ion beams than for X-rays. Visualization of complex DSBs in clinical specimens will help us to understand the anti-tumor effects of carbon ion radiotherapy. | |||||
| 書誌情報 |
Scientific reports 巻 6, p. 22275-1-22275-7, 発行日 2016-03 |
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| 出版者 | ||||||
| 出版者 | Nature Publishing Group | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2045-2322 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 26925533 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/srep22275 | |||||
