{"created":"2023-05-15T14:36:58.816654+00:00","id":47655,"links":{},"metadata":{"_buckets":{"deposit":"302d2aca-1bb3-4d37-9965-5549c807911c"},"_deposit":{"created_by":1,"id":"47655","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47655"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047655","sets":["1"]},"author_link":["478014","478003","478013","478004","478005","478012","478009","478007","478002","478008","478001","478010","478015","478016","478011","478006","478000"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"22275-7","bibliographicPageStart":"22275-1","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Scientific reports"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Carbon ion radiotherapy shows great potential as a cure for X-ray-resistant tumors. Basic research suggests that the strong cell-killing effect induced by carbon ions is based on their ability to cause complex DNA double-strand breaks (DSBs). However, evidence supporting the formation of complex DSBs in actual patients is lacking. Here, we used advanced high-resolution microscopy with deconvolution to show that complex DSBs are formed in a human tumor clinically treated with carbon ion radiotherapy, but not in a tumor treated with X-ray radiotherapy. Furthermore, analysis using a physics model suggested that the complexity of radiotherapy-induced DSBs is related to linear energy transfer, which is much higher for carbon ion beams than for X-rays. Visualization of complex DSBs in clinical specimens will help us to understand the anti-tumor effects of carbon ion radiotherapy.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"26925533","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/srep22275","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Oike, Takahiro"}],"nameIdentifiers":[{"nameIdentifier":"478000","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Niimi, Atsuko"}],"nameIdentifiers":[{"nameIdentifier":"478001","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okonogi, Noriyuki"}],"nameIdentifiers":[{"nameIdentifier":"478002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murata, Kazutoshi"}],"nameIdentifiers":[{"nameIdentifier":"478003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumura, Akihiko"}],"nameIdentifiers":[{"nameIdentifier":"478004","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noda, Shin-Ei"}],"nameIdentifiers":[{"nameIdentifier":"478005","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Daijiro"}],"nameIdentifiers":[{"nameIdentifier":"478006","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwanaga, Mototaro"}],"nameIdentifiers":[{"nameIdentifier":"478007","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuchida, Keisuke"}],"nameIdentifiers":[{"nameIdentifier":"478008","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanai, Tatsuaki"}],"nameIdentifiers":[{"nameIdentifier":"478009","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohno, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"478010","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibata, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"478011","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakano, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"478012","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小此木 範之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林 大二郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478014","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大野 達也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478015","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中野 隆史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478016","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Visualization of complex DNA double-strand breaks in a tumor treated with carbon ion radiotherapy.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Visualization of complex DNA double-strand breaks in a tumor treated with carbon ion radiotherapy."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-03-14"},"publish_date":"2017-03-14","publish_status":"0","recid":"47655","relation_version_is_last":true,"title":["Visualization of complex DNA double-strand breaks in a tumor treated with carbon ion radiotherapy."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:37:05.903851+00:00"}