@article{oai:repo.qst.go.jp:00047655,
 author = {Oike, Takahiro and Niimi, Atsuko and Okonogi, Noriyuki and Murata, Kazutoshi and Matsumura, Akihiko and Noda, Shin-Ei and Kobayashi, Daijiro and Iwanaga, Mototaro and Tsuchida, Keisuke and Kanai, Tatsuaki and Ohno, Tatsuya and Shibata, Atsushi and Nakano, Takashi and 小此木 範之 and 小林 大二郎 and 大野 達也 and 中野 隆史},
 journal = {Scientific reports},
 month = {Mar},
 note = {Carbon ion radiotherapy shows great potential as a cure for X-ray-resistant tumors. Basic research suggests that the strong cell-killing effect induced by carbon ions is based on their ability to cause complex DNA double-strand breaks (DSBs). However, evidence supporting the formation of complex DSBs in actual patients is lacking. Here, we used advanced high-resolution microscopy with deconvolution to show that complex DSBs are formed in a human tumor clinically treated with carbon ion radiotherapy, but not in a tumor treated with X-ray radiotherapy. Furthermore, analysis using a physics model suggested that the complexity of radiotherapy-induced DSBs is related to linear energy transfer, which is much higher for carbon ion beams than for X-rays. Visualization of complex DSBs in clinical specimens will help us to understand the anti-tumor effects of carbon ion radiotherapy.},
 pages = {22275-1--22275-7},
 title = {Visualization of complex DNA double-strand breaks in a tumor treated with carbon ion radiotherapy.},
 volume = {6},
 year = {2016}
}