WEKO3
アイテム
{"_buckets": {"deposit": "17384291-4750-4af5-b3c2-e0cd0e02f686"}, "_deposit": {"created_by": 1, "id": "47220", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "47220"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00047220", "sets": ["1"]}, "author_link": ["472097", "472101", "472098", "472093", "472096", "472100", "472084", "472074", "472076", "472077", "472070", "472081", "472090", "472091", "472072", "472103", "472104", "472067", "472102", "472094", "472099", "472086", "472075", "472078", "472087", "472071", "472073", "472069", "472079", "472089", "472085", "472083", "472068", "472088", "472080", "472082", "472092", "472095", "472066"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "943", "bibliographicPageStart": "937", "bibliographicVolumeNumber": "16", "bibliographic_titles": [{"bibliographic_title": "The International Journal of Neuropsychopharmacology"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Antidepressants used for treatment of depression exert their efficacy by blocking reuptake at serotonin transporters (5-HTT) and/or norepinephrine transporters (NET). Recent studies suggest that serotonin and norepinephrine reuptake inhibitors that block both 5-HTT and NET have better tolerability than tricyclic antidepressants and may have higher efficacy compared to selective serotonin reuptake inhibitors. Previous positron emission tomography (PET) studies have reported \u003e80% 5-HTT occupancy with clinical doses of antidepressants, but there has been no report of NET occupancy in patients treated with antidepressants. In the present study, we investigated both 5-HTT and NET occupancies by PET using radioligands [11C]DASB and (S,S)-[18F]FMeNER-D2, in six patients, each with major depressive disorder (MDD), using various doses of milnacipran. Our data show that mean 5-HTT occupancy in the thalamus was 33.0% at 50?mg, 38.6% at 100?mg, 60.0% at 150?mg and 61.5% at 200?mg. Mean NET occupancy in the thalamus was 25.3% at 25?mg, 40.0% at 100?mg, 47.3% at 125?mg and 49.9% at 200?mg. Estimated ED50 was 122.5?mg with the dose for 5-HTT and 149.9?mg for NET. Both 5-HTT and NET occupancies were observed in a dose-dependent manner. Both 5-HTT and NET occupancies were about 40% by milnacipran at 100?mg, the dose most commonly administered to MDD patients.", "subitem_description_type": "Abstract"}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "23067569", "subitem_relation_type_select": "PMID"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://journals.cambridge.org/action/displayAbstract?fromPage=online\u0026aid=8715686"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://journals.cambridge.org/action/displayAbstract?fromPage=online\u0026aid=8715686", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1461-1457", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nogami, Tsuyoshi"}], "nameIdentifiers": [{"nameIdentifier": "472066", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takano, Harumasa"}], "nameIdentifiers": [{"nameIdentifier": "472067", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Arakawa, Ryosuke"}], "nameIdentifiers": [{"nameIdentifier": "472068", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichimiya, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "472069", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujiwara, Hironobu"}], "nameIdentifiers": [{"nameIdentifier": "472070", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, Yasuyuki"}], "nameIdentifiers": [{"nameIdentifier": "472071", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kodaka, Fumitoshi"}], "nameIdentifiers": [{"nameIdentifier": "472072", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sasaki, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "472073", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahata, Keisuke"}], "nameIdentifiers": [{"nameIdentifier": "472074", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Masayuki"}], "nameIdentifiers": [{"nameIdentifier": "472075", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagashima, Tomohisa"}], "nameIdentifiers": [{"nameIdentifier": "472076", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mori, Takaaki"}], "nameIdentifiers": [{"nameIdentifier": "472077", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "472078", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukuda, Hajime"}], "nameIdentifiers": [{"nameIdentifier": "472079", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sekine, Mizuho"}], "nameIdentifiers": [{"nameIdentifier": "472080", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tateno, Amane"}], "nameIdentifiers": [{"nameIdentifier": "472081", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Hidehiko"}], "nameIdentifiers": [{"nameIdentifier": "472082", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "472083", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okubo, Yoshiro"}], "nameIdentifiers": [{"nameIdentifier": "472084", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suhara, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "472085", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "野上 毅", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472086", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高野 晴成", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472087", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "荒川 亮介", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472088", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "一宮 哲哉", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472089", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "藤原 広臨", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472090", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "木村 泰之", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472091", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小高 文聰", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472092", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "佐々木 健至", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472093", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高畑 圭輔", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472094", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鈴木 雅之", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472095", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "永嶌 朋久", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472096", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "森 崇明", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472097", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "島田 斉", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472098", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "関根 瑞保", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472099", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "舘野 周", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472100", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高橋 英彦", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472101", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "伊藤 浩", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472102", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "大久保 善朗", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472103", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "須原 哲也", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472104", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Occupancy of serotonin and norepinephrine transporter by milnacipran in patients with major depressive disorder: a positron emission tomography study with [11C]DASB and (S,S)-[18F]FMeNER-D2.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Occupancy of serotonin and norepinephrine transporter by milnacipran in patients with major depressive disorder: a positron emission tomography study with [11C]DASB and (S,S)-[18F]FMeNER-D2."}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/47220", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-08-06"}, "publish_date": "2015-08-06", "publish_status": "0", "recid": "47220", "relation": {}, "relation_version_is_last": true, "title": ["Occupancy of serotonin and norepinephrine transporter by milnacipran in patients with major depressive disorder: a positron emission tomography study with [11C]DASB and (S,S)-[18F]FMeNER-D2."], "weko_shared_id": -1}
Occupancy of serotonin and norepinephrine transporter by milnacipran in patients with major depressive disorder: a positron emission tomography study with [11C]DASB and (S,S)-[18F]FMeNER-D2.
https://repo.qst.go.jp/records/47220
https://repo.qst.go.jp/records/472205fdb0a67-63cb-4ba9-b950-77be17aa82d8
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2015-08-06 | |||||
タイトル | ||||||
タイトル | Occupancy of serotonin and norepinephrine transporter by milnacipran in patients with major depressive disorder: a positron emission tomography study with [11C]DASB and (S,S)-[18F]FMeNER-D2. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Nogami, Tsuyoshi
× Nogami, Tsuyoshi× Takano, Harumasa× Arakawa, Ryosuke× Ichimiya, Tetsuya× Fujiwara, Hironobu× Kimura, Yasuyuki× Kodaka, Fumitoshi× Sasaki, Takeshi× Takahata, Keisuke× Suzuki, Masayuki× Nagashima, Tomohisa× Mori, Takaaki× Shimada, Hitoshi× Fukuda, Hajime× Sekine, Mizuho× Tateno, Amane× Takahashi, Hidehiko× Ito, Hiroshi× Okubo, Yoshiro× Suhara, Tetsuya× 野上 毅× 高野 晴成× 荒川 亮介× 一宮 哲哉× 藤原 広臨× 木村 泰之× 小高 文聰× 佐々木 健至× 高畑 圭輔× 鈴木 雅之× 永嶌 朋久× 森 崇明× 島田 斉× 関根 瑞保× 舘野 周× 高橋 英彦× 伊藤 浩× 大久保 善朗× 須原 哲也 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Antidepressants used for treatment of depression exert their efficacy by blocking reuptake at serotonin transporters (5-HTT) and/or norepinephrine transporters (NET). Recent studies suggest that serotonin and norepinephrine reuptake inhibitors that block both 5-HTT and NET have better tolerability than tricyclic antidepressants and may have higher efficacy compared to selective serotonin reuptake inhibitors. Previous positron emission tomography (PET) studies have reported >80% 5-HTT occupancy with clinical doses of antidepressants, but there has been no report of NET occupancy in patients treated with antidepressants. In the present study, we investigated both 5-HTT and NET occupancies by PET using radioligands [11C]DASB and (S,S)-[18F]FMeNER-D2, in six patients, each with major depressive disorder (MDD), using various doses of milnacipran. Our data show that mean 5-HTT occupancy in the thalamus was 33.0% at 50?mg, 38.6% at 100?mg, 60.0% at 150?mg and 61.5% at 200?mg. Mean NET occupancy in the thalamus was 25.3% at 25?mg, 40.0% at 100?mg, 47.3% at 125?mg and 49.9% at 200?mg. Estimated ED50 was 122.5?mg with the dose for 5-HTT and 149.9?mg for NET. Both 5-HTT and NET occupancies were observed in a dose-dependent manner. Both 5-HTT and NET occupancies were about 40% by milnacipran at 100?mg, the dose most commonly administered to MDD patients. | |||||
書誌情報 |
The International Journal of Neuropsychopharmacology 巻 16, 号 5, p. 937-943, 発行日 2012-10 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1461-1457 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 23067569 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8715686 | |||||
関連名称 | http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8715686 |