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ROS Stress Resets Circadian Clocks to Coordinate Pro-Survival Signals.
https://repo.qst.go.jp/records/46696
https://repo.qst.go.jp/records/46696d23f07bd-7b6c-4ff8-b32e-f4c7ea545622
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-01-14 | |||||
タイトル | ||||||
タイトル | ROS Stress Resets Circadian Clocks to Coordinate Pro-Survival Signals. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Tamaru, Teruya
× Tamaru, Teruya× Ninomiya, Yasuharu× Hattori, Mitsuru× Varès, Guillaume× Kawamura, Genki× Honda, Kousuke× Prasad, Mishra Durga× Wang, Bing× Benjamin, Ivor× Sassone-Corsi, Paolo× Ozawa, Takeaki× Takamatsu, Ken× 二宮 康晴× Guillaume Vares× 王 冰 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Dysfunction of circadian clocks exacerbates various diseases, in part likely due to impaired stress resistance. It is unclear how circadian clock system responds toward critical stresses, to evoke life-protective adaptation. We identified a reactive oxygen species (ROS), H2O2 -responsive circadian pathway in mammals. Near-lethal doses of ROS-induced critical oxidative stress (cOS) at the branch point of life and death resets circadian clocks, synergistically evoking protective responses for cell survival. The cOS-triggered clock resetting and pro-survival responses are mediated by transcription factor, central clock-regulatory BMAL1 and heat shock stress-responsive (HSR) HSF1. Casein kinase II (CK2) -mediated phosphorylation regulates dimerization and function of BMAL1 and HSF1 to control the cOS-evoked responses. The core cOS-responsive transcriptome includes CK2-regulated crosstalk between the circadian, HSR, NF-kappa-B-mediated anti-apoptotic, and Nrf2-mediated anti-oxidant pathways. This novel circadian-adaptive signaling system likely plays fundamental protective roles in various ROS-inducible disorders, diseases, and death. | |||||
書誌情報 |
PloS one 巻 8, 号 12, p. e82006-e82006, 発行日 2013-12 |
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出版者 | ||||||
出版者 | 1932-6203 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1932-6203 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 24312621 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1371/journal.pone.0082006 |