@article{oai:repo.qst.go.jp:00046696,
 author = {Tamaru, Teruya and Ninomiya, Yasuharu and Hattori, Mitsuru and Varès, Guillaume and Kawamura, Genki and Honda, Kousuke and Prasad, Mishra Durga and Wang, Bing and Benjamin, Ivor and Sassone-Corsi, Paolo and Ozawa, Takeaki and Takamatsu, Ken and 二宮 康晴 and Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ and 王 冰},
 issue = {12},
 journal = {PloS one},
 month = {Dec},
 note = {Dysfunction of circadian clocks exacerbates various diseases, in part likely due to impaired stress resistance. It is unclear how circadian clock system responds toward critical stresses, to evoke life-protective adaptation. We identified a reactive oxygen species (ROS), H2O2 -responsive circadian pathway in mammals. Near-lethal doses of ROS-induced critical oxidative stress (cOS) at the branch point of life and death resets circadian clocks, synergistically evoking protective responses for cell survival. The cOS-triggered clock resetting and pro-survival responses are mediated by transcription factor, central clock-regulatory BMAL1 and heat shock stress-responsive (HSR) HSF1. Casein kinase II (CK2) -mediated phosphorylation regulates dimerization and function of BMAL1 and HSF1 to control the cOS-evoked responses. The core cOS-responsive transcriptome includes CK2-regulated crosstalk between the circadian, HSR, NF-kappa-B-mediated anti-apoptotic, and Nrf2-mediated anti-oxidant pathways. This novel circadian-adaptive signaling system likely plays fundamental protective roles in various ROS-inducible disorders, diseases, and death.},
 pages = {e82006--e82006},
 title = {ROS Stress Resets Circadian Clocks to Coordinate Pro-Survival Signals.},
 volume = {8},
 year = {2013}
}