{"created":"2023-05-15T14:36:16.427836+00:00","id":46696,"links":{},"metadata":{"_buckets":{"deposit":"026ab430-52bc-4267-b030-f116b3a71b86"},"_deposit":{"created_by":1,"id":"46696","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46696"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046696","sets":["1"]},"author_link":["465607","465609","465605","465614","465615","465604","465612","465610","465602","465608","465616","465603","465613","465606","465611"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"e82006","bibliographicPageStart":"e82006","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"PloS one"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Dysfunction of circadian clocks exacerbates various diseases, in part likely due to impaired stress resistance. It is unclear how circadian clock system responds toward critical stresses, to evoke life-protective adaptation. We identified a reactive oxygen species (ROS), H2O2 -responsive circadian pathway in mammals. Near-lethal doses of ROS-induced critical oxidative stress (cOS) at the branch point of life and death resets circadian clocks, synergistically evoking protective responses for cell survival. The cOS-triggered clock resetting and pro-survival responses are mediated by transcription factor, central clock-regulatory BMAL1 and heat shock stress-responsive (HSR) HSF1. Casein kinase II (CK2) -mediated phosphorylation regulates dimerization and function of BMAL1 and HSF1 to control the cOS-evoked responses. The core cOS-responsive transcriptome includes CK2-regulated crosstalk between the circadian, HSR, NF-kappa-B-mediated anti-apoptotic, and Nrf2-mediated anti-oxidant pathways. This novel circadian-adaptive signaling system likely plays fundamental protective roles in various ROS-inducible disorders, diseases, and death.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"1932-6203"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"24312621","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pone.0082006","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tamaru, Teruya"}],"nameIdentifiers":[{"nameIdentifier":"465602","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ninomiya, Yasuharu"}],"nameIdentifiers":[{"nameIdentifier":"465603","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hattori, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"465604","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Varès, Guillaume"}],"nameIdentifiers":[{"nameIdentifier":"465605","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawamura, Genki"}],"nameIdentifiers":[{"nameIdentifier":"465606","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Honda, Kousuke"}],"nameIdentifiers":[{"nameIdentifier":"465607","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Prasad, Mishra Durga"}],"nameIdentifiers":[{"nameIdentifier":"465608","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wang, Bing"}],"nameIdentifiers":[{"nameIdentifier":"465609","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Benjamin, Ivor"}],"nameIdentifiers":[{"nameIdentifier":"465610","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sassone-Corsi, Paolo"}],"nameIdentifiers":[{"nameIdentifier":"465611","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ozawa, Takeaki"}],"nameIdentifiers":[{"nameIdentifier":"465612","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takamatsu, Ken"}],"nameIdentifiers":[{"nameIdentifier":"465613","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"二宮 康晴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"465614","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"465615","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"465616","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ROS Stress Resets Circadian Clocks to Coordinate Pro-Survival Signals.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ROS Stress Resets Circadian Clocks to Coordinate Pro-Survival Signals."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-01-14"},"publish_date":"2014-01-14","publish_status":"0","recid":"46696","relation_version_is_last":true,"title":["ROS Stress Resets Circadian Clocks to Coordinate Pro-Survival Signals."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:48:43.395535+00:00"}