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The density of D2/3HIGH can be measured with (R)-2-11CH3O-N-n-propylnorapomorphine ([11C]MNPA), while total density of D2/3HIGH and D2/3LOW (D2/3Rs) can be measured with [11C]raclopride using positron emission tomography (PET). Thus, the ratio of the binding potential (BP) of [11C]MNPA to that of [11C]raclopride ([11C]MNPA/[11C]raclopride) may reflect the proportion of the density of D2/3HIGH to that of D2/3Rs. In the caudate and putamen, [11C]MNPA/[11C]raclopride reflects the proportion of the density of D2HIGH to that of D2Rs. To evaluate the reliability of the PET paradigm with [11C]MNPA and [11C]raclopride, we investigated the test-retest reproducibility of non-displaceable BP (BPND) measured with [11C]MNPA, and of [11C]MNPA/[11C]raclopride in healthy humans.\nMethods: Eleven healthy male volunteers underwent two sets of PET studies on separate days that each included [11C]MNPA and [11C]raclopride scans. BPND values in the caudate and putamen were calculated. Test-retest reproducibility of BPND of [11C]MNPA, and [11C]MNPA/[11C]raclopride, was assessed by intra-subject variability (absolute variability) and test-retest reliability (intra-class correlation coefficient: ICC). \nResults: The absolute variability of [11C]MNPA BPND was 5.30 +- 3.96% and 12.3 +- 7.95% and the ICC values of [11C]MNPA BPND were 0.72 and 0.82 in the caudate and putamen, respectively. The absolute variability of [11C]MNPA/[11C]raclopride was 6.11 +- 3.68% and 11.60 +- 5.70% and the ICC values of [11C]MNPA/[11C]raclopride were 0.79 and 0.80 in the caudate and putamen, respectively.\nConclusion: In the present preliminary study, the test-retest reproducibility of BPND of [11C]MNPA and of [11C]MNPA/[11C]raclopride was reliable in the caudate and putamen.", "subitem_description_type": "Abstract"}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1619-7070", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kodaka, Fumitoshi"}], "nameIdentifiers": [{"nameIdentifier": "463847", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "463848", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, Yasuyuki"}], "nameIdentifiers": [{"nameIdentifier": "463849", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujie, Saori"}], "nameIdentifiers": [{"nameIdentifier": "463850", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takano, Harumasa"}], "nameIdentifiers": [{"nameIdentifier": "463851", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujiwara, Hironobu"}], "nameIdentifiers": [{"nameIdentifier": "463852", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sasaki, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "463853", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakayama, Kazuhiko"}], "nameIdentifiers": [{"nameIdentifier": "463854", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Halldin, Christer"}], "nameIdentifiers": [{"nameIdentifier": "463855", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Farde, Lars"}], "nameIdentifiers": [{"nameIdentifier": "463856", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suhara, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "463857", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小高 文聰", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463858", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "伊藤 浩", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463859", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "木村 泰之", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463860", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "藤江 沙織", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463861", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高野 晴成", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463862", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "藤原 広臨", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463863", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "佐々木 健至", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463864", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ハルディン クリスタ", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463865", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "須原 哲也", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463866", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Test-retest reproducibility of dopamine D2/3 receptor binding in human brain measured by PET with [11C]MNPA and [11C]raclopride", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Test-retest reproducibility of dopamine D2/3 receptor binding in human brain measured by PET with [11C]MNPA and [11C]raclopride"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/46544", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-05-02"}, "publish_date": "2013-05-02", "publish_status": "0", "recid": "46544", "relation": {}, "relation_version_is_last": true, "title": ["Test-retest reproducibility of dopamine D2/3 receptor binding in human brain measured by PET with [11C]MNPA and [11C]raclopride"], "weko_shared_id": -1}
Test-retest reproducibility of dopamine D2/3 receptor binding in human brain measured by PET with [11C]MNPA and [11C]raclopride
https://repo.qst.go.jp/records/46544
https://repo.qst.go.jp/records/46544e9bf8573-9390-4b3f-9bbb-f6d3cbfd6969
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-05-02 | |||||
タイトル | ||||||
タイトル | Test-retest reproducibility of dopamine D2/3 receptor binding in human brain measured by PET with [11C]MNPA and [11C]raclopride | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Kodaka, Fumitoshi
× Kodaka, Fumitoshi× Ito, Hiroshi× Kimura, Yasuyuki× Fujie, Saori× Takano, Harumasa× Fujiwara, Hironobu× Sasaki, Takeshi× Nakayama, Kazuhiko× Halldin, Christer× Farde, Lars× Suhara, Tetsuya× 小高 文聰× 伊藤 浩× 木村 泰之× 藤江 沙織× 高野 晴成× 藤原 広臨× 佐々木 健至× ハルディン クリスタ× 須原 哲也 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose: Dopamine D2/3 receptors (D2/3Rs) have two affinity states for endogenous dopamine, referred to as high-affinity state (D2/3HIGH), which has a high affinity for endogenous dopamine, and low-affinity state (D2/3LOW). The density of D2/3HIGH can be measured with (R)-2-11CH3O-N-n-propylnorapomorphine ([11C]MNPA), while total density of D2/3HIGH and D2/3LOW (D2/3Rs) can be measured with [11C]raclopride using positron emission tomography (PET). Thus, the ratio of the binding potential (BP) of [11C]MNPA to that of [11C]raclopride ([11C]MNPA/[11C]raclopride) may reflect the proportion of the density of D2/3HIGH to that of D2/3Rs. In the caudate and putamen, [11C]MNPA/[11C]raclopride reflects the proportion of the density of D2HIGH to that of D2Rs. To evaluate the reliability of the PET paradigm with [11C]MNPA and [11C]raclopride, we investigated the test-retest reproducibility of non-displaceable BP (BPND) measured with [11C]MNPA, and of [11C]MNPA/[11C]raclopride in healthy humans. Methods: Eleven healthy male volunteers underwent two sets of PET studies on separate days that each included [11C]MNPA and [11C]raclopride scans. BPND values in the caudate and putamen were calculated. Test-retest reproducibility of BPND of [11C]MNPA, and [11C]MNPA/[11C]raclopride, was assessed by intra-subject variability (absolute variability) and test-retest reliability (intra-class correlation coefficient: ICC). Results: The absolute variability of [11C]MNPA BPND was 5.30 +- 3.96% and 12.3 +- 7.95% and the ICC values of [11C]MNPA BPND were 0.72 and 0.82 in the caudate and putamen, respectively. The absolute variability of [11C]MNPA/[11C]raclopride was 6.11 +- 3.68% and 11.60 +- 5.70% and the ICC values of [11C]MNPA/[11C]raclopride were 0.79 and 0.80 in the caudate and putamen, respectively. Conclusion: In the present preliminary study, the test-retest reproducibility of BPND of [11C]MNPA and of [11C]MNPA/[11C]raclopride was reliable in the caudate and putamen. |
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書誌情報 |
European Journal of Nuclear Medicine and Molecular Imaging 巻 40, 号 4, p. 574-579, 発行日 2013-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1619-7070 |