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Recent literature indicates that cancer cells expressing CD133, which is a frequently used marker for so-called cancer stem cells or cancer stem cell-like cells (collectively referred here as CSC\u0027s), contribute to tumor\u0027s therapeutic resistance and metastasis ability and possess hypoxia resistance. Here, we investigated relationships between 64Cu-\nATSM accumulation and existence of CD133+ cells using mouse colon carcinoma (Colon-26) tumor. \nMethods: Intratumor distribution of 64Cu-ATSM and 18F-fluorodeoxyglucose (18FDG) was compared with immunohistochemical staining for CD133 with a Colon-26 model. In addition, in vitro characterization of CD133+ Colon-26 cells was performed. \nResults: In Colon-26 tumors, 64Cu-ATSM localized preferentially in regions with a high density of CD133+ cells. The percentage of CD133+ cells was 11-fold higher in 64Cu-ATSM high uptake regions compared with 18FDG high (but 64Cu-ATSM low) uptake regions. CD133+ Colon-26 cells showed characteristics, which have been previously linked with CSC\u0027s in other cancer cell lines, such as high colony-forming ability, high tumor-initiating ability, and hypoxia resistance. In vitro culturing of Colon-\n26 cells under hypoxia and/or glucose starvation showed that CD133+ cells were resistant to hypoxia and glucose starvation, and 64Cu-ATSM uptake was increased under such conditions. \nConclusions: Our findings indicate that, in Colon-26 tumors, 64Cu-ATSM accumulates in CD133+ cell-rich regions and that CD133+ Colon-26 cells were highly tumorigenic and resistant to hypoxia and glucose starvation. Therefore 64Cu-ATSM could be a potential imaging agent for rich regions of CD133+ cells, associated with CSC\u0027s, within tumors.", "subitem_description_type": "Abstract"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.nucmedbio.2009.12.011", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0969-8051", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yoshii, Yukie"}], "nameIdentifiers": [{"nameIdentifier": "460389", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Furukawa, Takako"}], "nameIdentifiers": [{"nameIdentifier": "460390", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kiyono, Yasushi"}], "nameIdentifiers": [{"nameIdentifier": "460391", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Ryo"}], "nameIdentifiers": [{"nameIdentifier": "460392", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Waki, Atsuo"}], "nameIdentifiers": [{"nameIdentifier": "460393", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mori, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "460394", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshii, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "460395", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oh, Myungmi"}], "nameIdentifiers": [{"nameIdentifier": "460396", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Asai, Tatsuya"}], "nameIdentifiers": [{"nameIdentifier": "460397", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okazawa, Hidehiko"}], "nameIdentifiers": [{"nameIdentifier": "460398", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujibayashi, Yasuhisa"}], "nameIdentifiers": [{"nameIdentifier": "460399", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "et.al"}], "nameIdentifiers": [{"nameIdentifier": "460400", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "吉井 幸恵", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "460401", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "古川 高子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "460402", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "清野 泰", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "460403", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Copper-64-diacetyl-bis (N4-methylthiosemicarbazone) accumulates in rich regions of CD133+highly tumorigenic cells in mouse colon carcinoma", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Copper-64-diacetyl-bis (N4-methylthiosemicarbazone) accumulates in rich regions of CD133+highly tumorigenic cells in mouse colon carcinoma"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/46232", "pubdate": {"attribute_name": "公開日", "attribute_value": "2011-12-21"}, "publish_date": "2011-12-21", "publish_status": "0", "recid": "46232", "relation": {}, "relation_version_is_last": true, "title": ["Copper-64-diacetyl-bis (N4-methylthiosemicarbazone) accumulates in rich regions of CD133+highly tumorigenic cells in mouse colon carcinoma"], "weko_shared_id": -1}
Copper-64-diacetyl-bis (N4-methylthiosemicarbazone) accumulates in rich regions of CD133+highly tumorigenic cells in mouse colon carcinoma
https://repo.qst.go.jp/records/46232
https://repo.qst.go.jp/records/4623205b54a74-8d18-4fc7-9cec-67e2cbc51430
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-12-21 | |||||
タイトル | ||||||
タイトル | Copper-64-diacetyl-bis (N4-methylthiosemicarbazone) accumulates in rich regions of CD133+highly tumorigenic cells in mouse colon carcinoma | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Yoshii, Yukie
× Yoshii, Yukie× Furukawa, Takako× Kiyono, Yasushi× Watanabe, Ryo× Waki, Atsuo× Mori, Tetsuya× Yoshii, Hiroshi× Oh, Myungmi× Asai, Tatsuya× Okazawa, Hidehiko× Fujibayashi, Yasuhisa× et.al× 吉井 幸恵× 古川 高子× 清野 泰 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Introduction: 64Cu-diacetyl-bis (N4-methylthiosemicarbazone) (64Cu-ATSM) is a potential imaging agent of hypoxic tumor for use with PET. Recent literature indicates that cancer cells expressing CD133, which is a frequently used marker for so-called cancer stem cells or cancer stem cell-like cells (collectively referred here as CSC's), contribute to tumor's therapeutic resistance and metastasis ability and possess hypoxia resistance. Here, we investigated relationships between 64Cu- ATSM accumulation and existence of CD133+ cells using mouse colon carcinoma (Colon-26) tumor. Methods: Intratumor distribution of 64Cu-ATSM and 18F-fluorodeoxyglucose (18FDG) was compared with immunohistochemical staining for CD133 with a Colon-26 model. In addition, in vitro characterization of CD133+ Colon-26 cells was performed. Results: In Colon-26 tumors, 64Cu-ATSM localized preferentially in regions with a high density of CD133+ cells. The percentage of CD133+ cells was 11-fold higher in 64Cu-ATSM high uptake regions compared with 18FDG high (but 64Cu-ATSM low) uptake regions. CD133+ Colon-26 cells showed characteristics, which have been previously linked with CSC's in other cancer cell lines, such as high colony-forming ability, high tumor-initiating ability, and hypoxia resistance. In vitro culturing of Colon- 26 cells under hypoxia and/or glucose starvation showed that CD133+ cells were resistant to hypoxia and glucose starvation, and 64Cu-ATSM uptake was increased under such conditions. Conclusions: Our findings indicate that, in Colon-26 tumors, 64Cu-ATSM accumulates in CD133+ cell-rich regions and that CD133+ Colon-26 cells were highly tumorigenic and resistant to hypoxia and glucose starvation. Therefore 64Cu-ATSM could be a potential imaging agent for rich regions of CD133+ cells, associated with CSC's, within tumors. |
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書誌情報 |
Nuclear Medicine and Biology 巻 37, 号 4, p. 395-404, 発行日 2010-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0969-8051 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.nucmedbio.2009.12.011 |