WEKO3
アイテム
{"_buckets": {"deposit": "02f75b25-3213-4deb-b6d1-4c9c6bf4bf32"}, "_deposit": {"created_by": 1, "id": "46179", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "46179"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00046179", "sets": ["1"]}, "author_link": ["459837", "459839", "459836", "459835", "459833", "459838", "459834", "459832", "459840", "459841"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2/4", "bibliographicPageEnd": "496", "bibliographicPageStart": "491", "bibliographicVolumeNumber": "143", "bibliographic_titles": [{"bibliographic_title": "Radiation Protection Dosimetry"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "It is considered that the linear energy transfer (LET) may not be the ideal index for expressing the relative biological effective- ness (RBE) of cell killing for heavy-ion irradiation, as the ion-species dependencies have clearly been observed in the relation between LET and RBE derived from cell-survival fraction data. The previously measured survival fractions of four cell lines irra- diated by various ion species, employing the saturation-corrected dose-mean lineal energy, y*, instead of LET as the index of the RBE were therefore re-analysed. In the analysis, the initial slopes of the survival fractions, the so-called a-parameter in the linear-quadratic model, were plotted as a function of y*, which was calculated by the microdosimetric kinetic (MK) model implemented in the Particle and Heavy Ion Transport code System. It was found from the analysis that the ion-species depen- dencies observed in the relations between a and LET disappeared from those between a and y*, and their relations can be well reproduced by a simple equation derived from the MK model. These results clearly indicate the suitability of y* to be used in the estimation of the RBE of cell killing for heavy-ion irradiations, which is of great importance in the treatment planning of charged-particle therapy.", "subitem_description_type": "Abstract"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1093/rpd/ncq484", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0144-8420", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Sato, Tatsuhiko"}], "nameIdentifiers": [{"nameIdentifier": "459832", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Ritsuko"}], "nameIdentifiers": [{"nameIdentifier": "459833", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kase, Yuki"}], "nameIdentifiers": [{"nameIdentifier": "459834", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuruoka, Chizuru"}], "nameIdentifiers": [{"nameIdentifier": "459835", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Masao"}], "nameIdentifiers": [{"nameIdentifier": "459836", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Furusawa, Yoshiya"}], "nameIdentifiers": [{"nameIdentifier": "459837", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Niita, Koji"}], "nameIdentifiers": [{"nameIdentifier": "459838", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鶴岡 千鶴", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "459839", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鈴木 雅雄", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "459840", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "古澤 佳也", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "459841", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "ANALYSIS OF CELL-SURVIVAL FRACTIONS FOR HEAVY-ION IRRADIATIONS BASED ON MICRODOSIMETRIC KINETIC MODEL IMPLEMENTED IN THE PARTICLE AND HEAVY ION TRANSPORT CODE SYSTEM", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "ANALYSIS OF CELL-SURVIVAL FRACTIONS FOR HEAVY-ION IRRADIATIONS BASED ON MICRODOSIMETRIC KINETIC MODEL IMPLEMENTED IN THE PARTICLE AND HEAVY ION TRANSPORT CODE SYSTEM"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/46179", "pubdate": {"attribute_name": "公開日", "attribute_value": "2011-10-07"}, "publish_date": "2011-10-07", "publish_status": "0", "recid": "46179", "relation": {}, "relation_version_is_last": true, "title": ["ANALYSIS OF CELL-SURVIVAL FRACTIONS FOR HEAVY-ION IRRADIATIONS BASED ON MICRODOSIMETRIC KINETIC MODEL IMPLEMENTED IN THE PARTICLE AND HEAVY ION TRANSPORT CODE SYSTEM"], "weko_shared_id": -1}
ANALYSIS OF CELL-SURVIVAL FRACTIONS FOR HEAVY-ION IRRADIATIONS BASED ON MICRODOSIMETRIC KINETIC MODEL IMPLEMENTED IN THE PARTICLE AND HEAVY ION TRANSPORT CODE SYSTEM
https://repo.qst.go.jp/records/46179
https://repo.qst.go.jp/records/4617993841fa8-b37f-402a-9d81-ba7b64a294b9
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2011-10-07 | |||||
タイトル | ||||||
タイトル | ANALYSIS OF CELL-SURVIVAL FRACTIONS FOR HEAVY-ION IRRADIATIONS BASED ON MICRODOSIMETRIC KINETIC MODEL IMPLEMENTED IN THE PARTICLE AND HEAVY ION TRANSPORT CODE SYSTEM | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Sato, Tatsuhiko
× Sato, Tatsuhiko× Watanabe, Ritsuko× Kase, Yuki× Tsuruoka, Chizuru× Suzuki, Masao× Furusawa, Yoshiya× Niita, Koji× 鶴岡 千鶴× 鈴木 雅雄× 古澤 佳也 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | It is considered that the linear energy transfer (LET) may not be the ideal index for expressing the relative biological effective- ness (RBE) of cell killing for heavy-ion irradiation, as the ion-species dependencies have clearly been observed in the relation between LET and RBE derived from cell-survival fraction data. The previously measured survival fractions of four cell lines irra- diated by various ion species, employing the saturation-corrected dose-mean lineal energy, y*, instead of LET as the index of the RBE were therefore re-analysed. In the analysis, the initial slopes of the survival fractions, the so-called a-parameter in the linear-quadratic model, were plotted as a function of y*, which was calculated by the microdosimetric kinetic (MK) model implemented in the Particle and Heavy Ion Transport code System. It was found from the analysis that the ion-species depen- dencies observed in the relations between a and LET disappeared from those between a and y*, and their relations can be well reproduced by a simple equation derived from the MK model. These results clearly indicate the suitability of y* to be used in the estimation of the RBE of cell killing for heavy-ion irradiations, which is of great importance in the treatment planning of charged-particle therapy. | |||||
書誌情報 |
Radiation Protection Dosimetry 巻 143, 号 2/4, p. 491-496, 発行日 2010-12 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0144-8420 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/rpd/ncq484 |