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Magnetic resonance imaging of brain neuroblastoma based on nitroxide redox cycle
https://repo.qst.go.jp/records/46056
https://repo.qst.go.jp/records/46056d9768944-e6d6-4ba5-8989-cdfb9e517e1a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-05-23 | |||||
| タイトル | ||||||
| タイトル | Magnetic resonance imaging of brain neuroblastoma based on nitroxide redox cycle | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Zhelev, Zhivko
× Zhelev, Zhivko× Bakalova-Zheleva, Rumiana× Shibata, Sayaka× Veselina, Gadjeva× Aoki, Ichio× Ｚｈｅｌｅｖ Ｚｈｉｖｋｏ× バカロバ ルミアナ× 柴田 さやか× 青木 伊知男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In the present study we propose a new diagnostic methodology for non-invasive imaging of tissue red/ox activity in intact healthy and cancer-bearing mammalians, which allows a differentiation of cancer development from normal (healthy) condition. The method is based on red/ox cycle of cellpermeable nitroxide radicals and their MRI contrast properties, which makes them useful molecular sensors for tissue red/ox activity. The nitroxide radical (which is characterized by T1 contrast) participates in electron-transfer reactions with the intracellular reactive oxygen species and reducing equivalents with formation of non-contrast intermediate products, which is accompanied with MRI signal decay. The half-life of MRI signal decay (1/2) was used as a marker of tissue red/ox activity to the nitroxide probe. The experiments were conducted on healthy and cancer-bearing mice. The mice were under anesthesia during the MRI measurements. All measurements were conducted on 7 Tesla MRI. In healthy mice, the half-life of MRI signal decay in the selected regions of interest (ROI; brain and surrounding tissues) was considered as a reference steady-state value, which is indicative of tissue red/ox activity in norm. In cancer-bearing mice, the half-life of MRI signal decay in the same or similar ROI was markedly different from this reference value. The results demonstrated that the normal (healthy) tissues possessed a significantly higher reduction activity to the nitroxide probe in comparison with cancer tissue, which could be an appropriate diagnostic marker for carcinogenesis. |
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| 書誌情報 |
Trakia Journal of Sciences. Series Biomedical Sciences 巻 8, 号 2, p. 1-5, 発行日 2010 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1313-7050 | |||||
