{"created":"2023-05-15T14:35:48.059027+00:00","id":46056,"links":{},"metadata":{"_buckets":{"deposit":"38b95dca-df0b-466f-9eee-0f31daa2175a"},"_deposit":{"created_by":1,"id":"46056","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46056"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046056","sets":["1"]},"author_link":["458441","458440","458444","458439","458442","458438","458443","458436","458437"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"Trakia Journal of Sciences. Series Biomedical Sciences"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In the present study we propose a new diagnostic methodology for non-invasive imaging of tissue red/ox activity in intact healthy and cancer-bearing mammalians, which allows a differentiation of cancer development from normal (healthy) condition. The method is based on red/ox cycle of cellpermeable nitroxide radicals and their MRI contrast properties, which makes them useful molecular sensors for tissue red/ox activity. The nitroxide radical (which is characterized by T1 contrast) participates in electron-transfer reactions with the intracellular reactive oxygen species and reducing equivalents with formation of non-contrast intermediate products, which is accompanied with MRI signal decay. The half-life of MRI signal decay (1/2) was used as a marker of tissue red/ox activity to the nitroxide probe.\nThe experiments were conducted on healthy and cancer-bearing mice. The mice were under anesthesia during the MRI measurements. All measurements were conducted on 7 Tesla MRI.\nIn healthy mice, the half-life of MRI signal decay in the selected regions of interest (ROI; brain and surrounding tissues) was considered as a reference steady-state value, which is indicative of tissue red/ox activity in norm. In cancer-bearing mice, the half-life of MRI signal decay in the same or similar ROI was markedly different from this reference value. The results demonstrated that the normal (healthy) tissues possessed a significantly higher reduction activity to the nitroxide probe in comparison with cancer tissue, which could be an appropriate diagnostic marker for carcinogenesis.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1313-7050","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zhelev, Zhivko"}],"nameIdentifiers":[{"nameIdentifier":"458436","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bakalova-Zheleva, Rumiana"}],"nameIdentifiers":[{"nameIdentifier":"458437","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibata, Sayaka"}],"nameIdentifiers":[{"nameIdentifier":"458438","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Veselina, Gadjeva"}],"nameIdentifiers":[{"nameIdentifier":"458439","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"458440","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｚｈｅｌｅｖ Ｚｈｉｖｋｏ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458441","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"バカロバ ルミアナ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458442","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柴田 さやか","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458443","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458444","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Magnetic resonance imaging of brain neuroblastoma based on nitroxide redox cycle","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Magnetic resonance imaging of brain neuroblastoma based on nitroxide redox cycle"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-05-23"},"publish_date":"2011-05-23","publish_status":"0","recid":"46056","relation_version_is_last":true,"title":["Magnetic resonance imaging of brain neuroblastoma based on nitroxide redox cycle"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:56:23.167602+00:00"}