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Positron emission tomography: quantitative measurement of brain acetylcholinesterase activity using radiolabeled substrates
https://repo.qst.go.jp/records/44417
https://repo.qst.go.jp/records/44417d14677cd-f3b6-46c6-8706-42daecf4d15a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-07-06 | |||||
| タイトル | ||||||
| タイトル | Positron emission tomography: quantitative measurement of brain acetylcholinesterase activity using radiolabeled substrates | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Namba, Hiroki
× Namba, Hiroki× Fukushi, Kiyoshi× Nagatsuka, Shin-ichiro× Iyo, Masaomi× Shinotoh, Hitoshi× Tanada, Shuji× Irie, Toshiaki× 難波 宏樹× 福士 清× 長塚 伸一郎× 篠遠 仁× 棚田 修二× 入江 俊章 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A new method for quantitative measurement of brain acetylcholinesterase(AChE) activity in living human brain using positron emission tomography(PET) is described. We tested several radiolabeled lipophilic acetylcholine analogs, e.g., N-methylpiperidyl esters, which readily entered the brain via the blood-brain barrier, were hydrolyzed sselectively by AChE, and were then trapped in the brain. Among them, and tested and N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) was chosen as the tracer for PET. Quantitative measurement of cortical AChE was accomplished by fitting the time course of cerebral radioactivity concentration measured by PET and the metabolite-corrected arterial plasma input function using a nonlinear least-squares fitting method. Normal control studies with a wide range in age(24-89 years) showed no decrease in AChE activity in the cerebral cortex with age. Studies on patients with Alzheimers disease demonstrated a widespread reduction of AChE activity in the cerebral cortex (more profound in early-onse than in late-onset Alzheimers disease). Parkinsons disease and progressive supranuclear palsy, clinically similar disorders, could be differentiated with [11C]MP4A/PET studies. Simple methods without using an arterial input function are also proposed. The method provides a quantitative measure ot the cholinergic aspect of brain function and proved to be useful in diagnosis of neurodegenerative disorders including Alzheimers disease. | |||||
| 書誌情報 |
Methods 巻 27, p. 242-250, 発行日 2002 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1046-2023 | |||||
