{"created":"2023-05-15T14:34:22.650644+00:00","id":44417,"links":{},"metadata":{"_buckets":{"deposit":"f29cd698-24f7-436d-8971-7a4c294744d1"},"_deposit":{"created_by":1,"id":"44417","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44417"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044417","sets":["1"]},"author_link":["441403","441406","441401","441402","441404","441396","441407","441395","441398","441397","441399","441400","441405"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"250","bibliographicPageStart":"242","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"Methods"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A new method for quantitative measurement of brain acetylcholinesterase(AChE) activity in living human brain using positron emission tomography(PET) is described. We tested several radiolabeled lipophilic acetylcholine analogs, e.g., N-methylpiperidyl esters, which readily entered the brain via the blood-brain barrier, were hydrolyzed sselectively by AChE, and were then trapped in the brain. Among them, and tested and N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) was chosen as the tracer for PET. Quantitative measurement of cortical AChE was accomplished by fitting the time course of cerebral radioactivity concentration measured by PET and the metabolite-corrected arterial plasma input function using a nonlinear least-squares fitting method. Normal control studies with a wide range in age(24-89 years) showed no decrease in AChE activity in the cerebral cortex with age. Studies on patients with Alzheimers disease demonstrated a widespread reduction of AChE activity in the cerebral cortex (more profound in early-onse than in late-onset Alzheimers disease). Parkinsons disease and progressive supranuclear palsy, clinically similar disorders, could be differentiated with [11C]MP4A/PET studies. Simple methods without using an arterial input function are also proposed. The method provides a quantitative measure ot the cholinergic aspect of brain function and proved to be useful in diagnosis of neurodegenerative disorders including Alzheimers disease.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1046-2023","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Namba, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"441395","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukushi, Kiyoshi"}],"nameIdentifiers":[{"nameIdentifier":"441396","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagatsuka, Shin-ichiro"}],"nameIdentifiers":[{"nameIdentifier":"441397","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iyo, Masaomi"}],"nameIdentifiers":[{"nameIdentifier":"441398","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinotoh, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"441399","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanada, Shuji"}],"nameIdentifiers":[{"nameIdentifier":"441400","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Irie, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"441401","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"難波 宏樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"441402","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士 清","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"441403","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長塚 伸一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"441404","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"441405","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"棚田 修二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"441406","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"441407","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Positron emission tomography: quantitative measurement of brain acetylcholinesterase activity using radiolabeled substrates","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Positron emission tomography: quantitative measurement of brain acetylcholinesterase activity using radiolabeled substrates"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-07-06"},"publish_date":"2006-07-06","publish_status":"0","recid":"44417","relation_version_is_last":true,"title":["Positron emission tomography: quantitative measurement of brain acetylcholinesterase activity using radiolabeled substrates"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:15:42.096994+00:00"}