WEKO3
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Different sensitivities to competitive inhibition of benzodiazepine receptor binding of 11C-iomazenil and 11C-flumazenil in rhesus monkey brain
https://repo.qst.go.jp/records/44307
https://repo.qst.go.jp/records/443070b0b2333-eec6-4906-84a6-67a21aedf633
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2006-06-21 | |||||
タイトル | ||||||
タイトル | Different sensitivities to competitive inhibition of benzodiazepine receptor binding of 11C-iomazenil and 11C-flumazenil in rhesus monkey brain | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Inoue, Osamu
× Inoue, Osamu× Hosoi, Rie× Kobayashi, Kaoru× Itoh, Takashi× Gee, Antony× Suzuki, Kazutoshi× 井上 修× 細井 理恵× 鈴木 和年 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The in vivo binding kinetics of 11C-iomazenil were compared with those of 11C-flumazenil binding in rhesus monkey brain.The monkey was anesthetized with ketamine and intravenously injected with either 11C-iomazenil or 11C-flumazenil in combination with the coadministration of different doses of non-radioactive flumazenil (0.5and20 mug/kg). The regional distribution of 11C-iomazenil in the brain was similar to that of 11C-flumazenil,but the sensitivity of 11C-iomazenil binding to competitive inhibition by non-radioactive flumazenil was much less than that of 11C-flumazenil binding. A significant reduction in 11C-flumazenil binding in the cerebral cortex was observed with 20mug/kg of flumazenil,whereas a relatively smaller inhibition of 11C-iomazenil binding in the same region was observed with the same dose of flumazenil. These results suggest that 11C-flumazenil may be a superior radiotracer for estimating benzodiazepine receptor occupancy in the intact brain. |
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書誌情報 |
Annals of Nuclear Medicine 巻 15, 号 2, p. 137-139, 発行日 2001 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0914-7187 |