{"created":"2023-05-15T14:34:15.382108+00:00","id":44307,"links":{},"metadata":{"_buckets":{"deposit":"8f995b3d-ea0e-45bf-b6b7-15aabbc52692"},"_deposit":{"created_by":1,"id":"44307","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44307"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044307","sets":["1"]},"author_link":["440097","440096","440095","440098","440092","440099","440094","440091","440093"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"139","bibliographicPageStart":"137","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"Annals of Nuclear Medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The in vivo binding kinetics of 11C-iomazenil were compared with those of 11C-flumazenil binding in rhesus monkey brain.The monkey was anesthetized with ketamine and intravenously injected with either 11C-iomazenil or 11C-flumazenil in combination with the coadministration of different doses of non-radioactive flumazenil (0.5and20 mug/kg).\n The regional distribution of 11C-iomazenil in the brain was similar to that of 11C-flumazenil,but the sensitivity of 11C-iomazenil binding to competitive inhibition by non-radioactive flumazenil was much less than that of 11C-flumazenil binding. A significant reduction in 11C-flumazenil binding in the cerebral cortex was observed with 20mug/kg of flumazenil,whereas a relatively smaller inhibition of 11C-iomazenil binding in the same region was observed with the same dose of flumazenil. These results suggest that 11C-flumazenil may be a superior radiotracer for estimating benzodiazepine receptor occupancy in the intact brain.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0914-7187","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Inoue, Osamu"}],"nameIdentifiers":[{"nameIdentifier":"440091","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hosoi, Rie"}],"nameIdentifiers":[{"nameIdentifier":"440092","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"440093","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Itoh, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"440094","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Gee, Antony"}],"nameIdentifiers":[{"nameIdentifier":"440095","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Kazutoshi"}],"nameIdentifiers":[{"nameIdentifier":"440096","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"井上 修","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440097","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"細井 理恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440098","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 和年","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440099","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Different sensitivities to competitive inhibition of benzodiazepine receptor binding of 11C-iomazenil and 11C-flumazenil in rhesus monkey brain","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Different sensitivities to competitive inhibition of benzodiazepine receptor binding of 11C-iomazenil and 11C-flumazenil in rhesus monkey brain"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-06-21"},"publish_date":"2006-06-21","publish_status":"0","recid":"44307","relation_version_is_last":true,"title":["Different sensitivities to competitive inhibition of benzodiazepine receptor binding of 11C-iomazenil and 11C-flumazenil in rhesus monkey brain"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:17:00.047650+00:00"}