@article{oai:repo.qst.go.jp:00044307,
 author = {Inoue, Osamu and Hosoi, Rie and Kobayashi, Kaoru and Itoh, Takashi and Gee, Antony and Suzuki, Kazutoshi and 井上 修 and 細井 理恵 and 鈴木 和年},
 issue = {2},
 journal = {Annals of Nuclear Medicine},
 month = {},
 note = {The in vivo binding kinetics of 11C-iomazenil were compared with those of 11C-flumazenil binding in rhesus monkey brain.The monkey was anesthetized with ketamine and intravenously injected with either 11C-iomazenil or 11C-flumazenil in combination with the coadministration of different doses of non-radioactive flumazenil (0.5and20 mug/kg).
 The regional distribution of 11C-iomazenil in the brain was similar to that of 11C-flumazenil,but the sensitivity of 11C-iomazenil binding to competitive inhibition by non-radioactive flumazenil was much less than that of 11C-flumazenil binding. A significant reduction in 11C-flumazenil binding in the cerebral cortex was observed with 20mug/kg of flumazenil,whereas a relatively smaller inhibition of 11C-iomazenil binding in the same region was observed with the same dose of flumazenil. These results suggest that 11C-flumazenil may be a superior radiotracer for estimating benzodiazepine receptor occupancy in the intact brain.},
 pages = {137--139},
 title = {Different sensitivities to competitive inhibition of benzodiazepine receptor binding of 11C-iomazenil and 11C-flumazenil in rhesus monkey brain},
 volume = {15},
 year = {2001}
}