量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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It is extremely important to take measure the effects of space radiation on the human body to forecast and defend them. Especially, reproduction and development in space will be an issue of high priority considering a long-term stay in space. We will launch frozen mouse ES cells and iPS cells into space, to expose them to space radiation. After storage at -80 degree in C in space for several months or years, the cells will be returned to the ground. We will microinject the ES or iPS cells into fertilized eggs to produce mice to examine the influence of space radiation on their development and on their descendents.
We used iron ion and carbon ion beam by accelerator of HIMAC of National Institute of Radiological Sciences as a ground-based experiment. The embryonic stem cells and iPS cells were irradiated with those beams and microinjected to mouse embryos, and subsequently transplanted to the uterus of pseudopregnant mice. We analyzed their survival, proliferation, and development.
会議概要（会議名, 開催地, 会期, 主催者等）
21st Annual NASA Space Radiation Investigators’ Workshop
Study on the effect of space radiation to mammalian ES and iPS cells to their development
