@misc{oai:repo.qst.go.jp:00065272, author = {Yoshida, Kayo and Yoshida, Syuhei and Eguchi-Kasai, Kiyomi and Morita, Takashi and 吉田 佳世 and 吉田 周平 and 笠井 清美 and 森田 隆}, month = {May}, note = {It is extremely important to take measure the effects of space radiation on the human body to forecast and defend them. Especially, reproduction and development in space will be an issue of high priority considering a long-term stay in space. We will launch frozen mouse ES cells and iPS cells into space, to expose them to space radiation. After storage at -80 degree in C in space for several months or years, the cells will be returned to the ground. We will microinject the ES or iPS cells into fertilized eggs to produce mice to examine the influence of space radiation on their development and on their descendents. We used iron ion and carbon ion beam by accelerator of HIMAC of National Institute of Radiological Sciences as a ground-based experiment. The embryonic stem cells and iPS cells were irradiated with those beams and microinjected to mouse embryos, and subsequently transplanted to the uterus of pseudopregnant mice. We analyzed their survival, proliferation, and development., 21st Annual NASA Space Radiation Investigators’ Workshop}, title = {Study on the effect of space radiation to mammalian ES and iPS cells to their development}, year = {2010} }