量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Poupose: To determine if Cu-62 labeled diacetyl-bis (N (4)-methylthiosemicarbazone); (Cu-62-ATSM) imaging of tumor hypoxia is associated with C-11-methionine(MET) imaging of amino acid metabolism in cervical cancer.
\nMethod: PET/CT was performed in ten patients with cervical cancer for evaluation of both tumor hypoxia using Cu-62-ATSM and amino acid metabolism using MET. Histologically confirmed eight squamous cell carcinoma, four adenocarcima, two adenosquamous carcinoma and melanoma were enrolled in this study. Distribution of Cu-62-ATSM in tumor was compared with that of MET. The two-group system was evaluated the distribution of uptake as Matched (mostly matched with each other) and Mismatched (with each other). Tumor uptake of each tracer was also analyzed semi-quantitatively by Tumor-to-Normal-Tissue-Ratio (TNR).
\nResult: Matched and Mismatched-groups were 1 case (6.7%) and 14 cases (93.3%), respectively. In Mismatched-group, Cu-62-ATSM tend to accumulate around the distal margin of high MET uptake area in the tumor. Mean TNR was 9.5 in MET and 4.0 in Cu-62-ATSM, and thus image contrast between tumor and surrounding normal tissue was higher in MET PET/CT image than Cu-62-ATSM PET/CT image.
\nConclusion: Cu-62-ATSM and MET showed different distribution in most cases of cervical cancer. Cervical cancer had a greater tendency for the uptake of MET than Cu-62-ATSM.
子宮頸癌における重粒子線治療前後のMethionine-PETと62CuATSM-PET診断の比較研究
