量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum Science and Technology.
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Intrroduction:It has been establishied in vitro that dopamine D2 receptor could be classified into two inrweconvertible affinity states to natural agonist dopamine,
the high-and low-affinity states.Dopamine D2 receotir binding in vivo has wildly been measured by PET with the use of antagonist radioligands,such as[11C]racloprode,however,the high-ans low-ahhinity states of dopamine D2 receptors can be distinguished by the antagonist radiologands.(R)-2-11CH3O-N-n-propylnorapomorphine([11C]MNPA)has recentaly been devdeloped as a potent new agonist for in vivo imaging of the high-affinity state of dopamine D2 receptors[1]. In presentstudy,the kinetics of[11C]MNPA in the without an arterial input function wewe alos validated.
Quantative analysis of dopaine D2 receptor binding in human brain using PET with a agonist redioligand[11C]MNPA
