量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人 量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。 Welcome to QST-Repository where we accumulates and discloses the academic research results(Journal Publications, Conference presentation, Research and Development Report, Patent, etc.) of the members of National Institutes for Quantum and Radiological Science and Technology.
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Preliminary Results from a Multi-center Prospective Study (JROSG 05-5) on Postoperative Radiotherapy for Patients with High-risk Ductal Carcinoma in situ with Involved Margins or Margin Widths 1 mm or less than
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Purpose: This prospective study aimed to evaluate the effectiveness of postoperative radiotherapy (PORT) consisting of whole breast irradiation followed by boost irradiation in patients with high-risk ductal carcinoma in situ
(DCIS) with margin widths less than 1mm.
Materials and Methods:A multi-center phase II study (Japanese Radiation Oncology Study Group: JROSG 05-5) was conducted to evaluate the effectiveness of PORT. PORT consisted of whole breast irradiation (50Gy/25 fractions) followed by boost irradiation (10Gy/5 fractions) using electron beams for patients with high-risk DCIS. Eligibility criteria were as follows:
1)DCIS without an invasive carcinoma component, 2)age between 20 and 80 years, 3) involved margins or margin widths less than 1 mm, 4) refusal of re-resection, 5) performance status of 0−2, and 6) written informed consent. The primary endpoint was ipsilateral breast tumor recurrence (IBTR), and secondary endpoints were overall survival, relapse free survival, recurrence patterns, and adverse events.
Preliminary Results from a Multi-center Prospective Study (JROSG 05-5) on Postoperative Radiotherapy for Patients with High-risk Ductal Carcinoma in situ with Involved Margins or Margin Widths 1 mm or less than
