doi:10.1093/jrr/rrs128

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量研学術機関リポジトリ「QST-Repository」は、国立研究開発法人量子科学技術研究開発機構に所属する職員等が生み出した学術成果（学会誌発表論文、学会発表、研究開発報告書、特許等）を集積しインターネット上で広く公開するサービスです。
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Permalink : http://id.nii.ac.jp/1657/00046549/

Nature of nontargeted radiation effects observed during fractionated irradiation-induced thymic lymphomagenesis in mice 利用統計を見る

アイテムタイプ	学術雑誌論文 / Journal Article
言語	英語
著者	Tsuji Hideo Ishii-Ohba Hiroko Shiomi Tadahiro Shiomi Naoko Katsube Takanori Mori Masahiko Nenoi Mitsuru Nakabeppu Yusaku Tatsumi Kouichi Muto Masahiro Sado Toshihiko et.al
抄録	Changes in the thymic microenvironment lead to radiation-induced thymic lymphomagenesis, but the phenomena are not fully understood. Here we show that radiation-induced chromosomal instability and bystander effects occur in thymocytes and are involved in lymphomagenesis in C57BL/6 mice that have been irradiated four times with 1.8-Gy gamma-rays. Reactive oxygen species (ROS) were generated in descendants of irradiated thymocytes during recovery from radiation-induced thymic atrophy. Concomitantly, descendants of irradiated thymocytes manifested DNA lesions as revealed by gamma-H2AX foci, chromosomal instability, aneuploidy with trisomy 15 and bystander effects on chromosomal aberration induction in co-cultured ROS-sensitive mutant cells, suggesting that the delayed generation of ROS is a primary cause of these phenomena. Abolishing the bystander effect of post-irradiation thymocytes by superoxide dismutase and catalase supports ROS involvement. Chromosomal instability in thymocytes resulted in the generation of abnormal cell clones bearing trisomy 15 and aberrant karyotypes in the thymus. The emergence of thymic lymphomas from the thymocyte population containing abnormal cell clones indicated that clones with trisomy 15 and altered karyotypes were prelymphoma cells with the potential to develop into thymic lymphomas. The oncogene Notch1 was rearranged after the prelymphoma cells were established. Thus, delayed nontargeted radiation effects drive thymic lymphomagenesis through the induction of characteristic changes in intrathymic immature T cells and the generation of prelymphoma cells.
雑誌名	Journal of Radiation Research
巻	54
ページ	453 - 466
発行年	2013-01
ISSN	0449-3060
DOI	10.1093/jrr/rrs128
著者版フラグ	none

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