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Observation of Liquid-Liquid Phase Separation of FUS-LC using Synchrotron CD Spectroscopy
https://repo.qst.go.jp/records/86600
https://repo.qst.go.jp/records/86600023aff95-92cc-4df7-a252-f8f7461aa2bc
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-07-25 | |||||
| タイトル | ||||||
| タイトル | Observation of Liquid-Liquid Phase Separation of FUS-LC using Synchrotron CD Spectroscopy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kentaro, Fujii
× Kentaro, Fujii× Nobuo, Maita× Koichi, Matsuo (Hiroshima University)× Masato, Kato× Kentaro, Fujii× Nobuo, Maita× Masato, Kato |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aggregation of the RNA-binding protein FUS (Fused in Sarcoma) has been implicated in the neurodegenerative diseases such as ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia). The low-complexity domain of the FUS (FUS-LC) mediated liquid-liquid phase separation (LLPS), but the structural mechanism is not known in detail. To address the revealing the mechanism, we examined the spectroscopic study using synchrotron CD measurement, which can analyze the secondary structure of the proteins. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 18th International Conference on Chiroptical Spectroscopy (CD2022) | |||||
| 発表年月日 | ||||||
| 日付 | 2022-07-26 | |||||
| 日付タイプ | Issued | |||||
