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Quantitative measurement of diffusion-weighted imaging signal using expression-controlled aquaporin-4 cells: Comparative study of 2-compartment and diffusion kurtosis imaging models.
https://repo.qst.go.jp/records/86548
https://repo.qst.go.jp/records/86548cd3f2549-c26d-44cc-bd6f-a4a3448331cb
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-07-12 | |||||
タイトル | ||||||
タイトル | Quantitative measurement of diffusion-weighted imaging signal using expression-controlled aquaporin-4 cells: Comparative study of 2-compartment and diffusion kurtosis imaging models. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Imaizumi, Akiko
× Imaizumi, Akiko× Obata, Takayuki× Kershaw, Jeff× Tachibana, Yasuhiko× Abe, Yoichiro× Shibata, Sayaka× Nitta, Nobuhiro× Aoki, Ichio× Yasui, Masato× Higashi, Tatsuya× Akiko, Imaizumi× Takayuki, Obata× Kershaw, Jeffrey× Yasuhiko, Tachibana× Sayaka, Shibata× Nobuhiro, Nitta× Ichio, Aoki× Tatsuya, Higashi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The purpose of this study was to compare parameter estimates for the 2-compartment and diffusion kurtosis imaging models obtained from diffusion-weighted imaging (DWI) of aquaporin-4 (AQP4) expression-controlled cells, and to look for biomarkers that indicate differences in the cell membrane water permeability. DWI was performed on AQP4-expressing and non-expressing cells and the signal was analyzed with the 2-compartment and diffusion kurtosis imaging models. For the 2-compartment model, the diffusion coefficients (Df, Ds) and volume fractions (Ff, Fs, Ff = 1-Fs) of the fast and slow compartments were estimated. For the diffusion kurtosis imaging model, estimates of the diffusion kurtosis (K) and corrected diffusion coefficient (D) were obtained. For the 2-compartment model, Ds and Fs showed clear differences between AQP4-expressing and non-expressing cells. Fs was also sensitive to cell density. There was no clear relationship with the cell type for the diffusion kurtosis imaging model parameters. Changes to cell membrane water permeability due to AQP4 expression affected DWI of cell suspensions. For the 2-compartment and diffusion kurtosis imaging models, Ds was the parameter most sensitive to differences in AQP4 expression. | |||||
書誌情報 |
PloS one 発行日 2022-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1932-6203 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 35439261 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1371/journal.pone.0266465 |