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中性子線の生物学的影響：概説
https://repo.qst.go.jp/records/86495
https://repo.qst.go.jp/records/864957dc9d7f7-7139-4332-8298-bad236fd6672
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-07-07 | |||||
| タイトル | ||||||
| タイトル | 中性子線の生物学的影響：概説 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
今岡, 達彦
× 今岡, 達彦× Tatsuhiko, Imaoka |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Exposure of human body to neutrons occurs in radiotherapy using high-energy radiations. This review summarizes knowledges related to biological effects of neutrons, including those obtained in recent projects in Japan and Europe. A study of Japanese atomic bomb survivors with recently revised dosimetry indicated very high relative biological effectiveness (RBE) of 25–80 (as point estimates) regarding cancer risk. Animal studies indicate RBE of 2–100 or even higher regarding cancer induction, which seem to have a peak around ~1 MeV. Evidence suggests that these values depend on the age and sex. Reported RBE regarding the effects on the lens of the eye is in a similar range and sometimes very high. Regarding other tissue reactions, reported RBE values range from 2–10. Experiments at the cellular level have reported RBE of 1–5 regarding cell killing, 2–20 regarding induction of mutations (with a peak at ~1 MeV), and ~1 regarding induction of DNA double strand breaks. A simulation study predicted that the RBE of induction of complex DNA breaks peaks at ~1 MeV with a value of ~17. The complex breaks produced are likely to be far less in amount than simple DNA breaks, leading to a subtle increase in the yield of total DNA breaks; however, these complex damages may be very efficient in inducing mutations and cancer. Thus, the combination of the yield of complex DNA damage and its efficacy in inducing cancer is considered to underlie the high RBE of neutrons regarding cancer risk. | |||||
| 書誌情報 |
医学物理 巻 42, 号 2, p. 73-79, 発行日 2022-07 |
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| 出版者 | ||||||
| 出版者 | 日本医学物理学会機関誌 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1345-5354 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/jjmp/42/2/42_73/_article/-char/ja | |||||
