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Uranium chelating ability of decorporation agents in serum evaluated by X-ray absorption spectroscopy
https://repo.qst.go.jp/records/86404
https://repo.qst.go.jp/records/8640477e8492d-0d86-4363-907e-afb8a0cb5c9e
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-06-28 | |||||
| タイトル | ||||||
| タイトル | Uranium chelating ability of decorporation agents in serum evaluated by X-ray absorption spectroscopy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Akihiro, Uehara
× Akihiro, Uehara× Daiju, Matsumura× Takuya, Tsuji× Haruko, Yakumaru× Izumi, Tanaka× Ayumi, Shiro× Hiroyuki, Saito× Hiroshi, Ishihara× Shino, Takeda× Akihiro, Uehara× Haruko, Yakumaru× Izumi, Tanaka× Ayumi, Shiro× Hiroyuki, Saito× Hiroshi, Ishihara× Shino, Takeda |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Internal exposure to actinides such as uranium and plutonium has been reduced using chelating agents for decorporation because of their potential to induce both radiological and chemical toxicities. This study measures uranium chemical forms in serum in the presence and absence of chelating agents based on X-ray absorption spectroscopy (XAS). The chelating agents used were 1-hydroxyethane 1,1-bisphosphonate (EHBP), inositol hexaphosphate (IP6), deferoxamine B (DFO), and diethylenetriaminepentaacetate (DTPA). Percentages of uranium–chelating agents and uranium–bioligands (bioligands: inorganic and organic ligands coordinating with uranium) dissolving in the serum were successfully evaluated based on principal component analysis of XAS spectra. The main ligands forming complexes with uranium in the serum were estimated as follows: IP6 > EHBP > bioligands > DFO >> DTPA when the concentration ratio of the chelating agent to uranium was 10. Measurements of uranium chemical forms and their concentrations in the serum would be useful for the appropriate treatment using chelating agents for the decorporation of uranium. | |||||
| 書誌情報 |
Analytical Methods 巻 14, 号 24, p. 2439-2445, 発行日 2022-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1759-9660 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1039/d2ay00565d | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | DOI https://doi.org/10.1039/D2AY00565D | |||||
