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Measurement of biological washout rates depending on tumor vascular status in 15O in-beam rat-PET
https://repo.qst.go.jp/records/86336
https://repo.qst.go.jp/records/86336b493f19b-dcb2-48e0-bc9c-e6199bc618c9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-06-20 | |||||
| タイトル | ||||||
| タイトル | Measurement of biological washout rates depending on tumor vascular status in 15O in-beam rat-PET | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Chie, Toramatsu
× Chie, Toramatsu× Mohammadi, Akram× Hidekatsu, Wakizaka× Hitomi, Sudo× Nobuhiro, Nitta× Chie, Seki× Miwako, Takahashi× Iwao, Kanno× Kumiko, Karasawa× Yoshiyuki, Hirano× Taiga, Yamaya× Chie, Toramatsu× Mohammadi, Akram× Hidekatsu, Wakizaka× Hitomi, Sudo× Nobuhiro, Nitta× Chie, Seki× Miwako, Takahashi× Iwao, Kanno× Kumiko, Karasawa× Yoshiyuki, Hirano× Taiga, Yamaya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective. The biological washout of positron emitters should be modeled and corrected in order to achieve quantitative dose range verification in charged particle therapy based on positron emission tomography (PET). This biological washout effect is affected by physiological environmental conditions such as blood perfusion and metabolism, but the correlation to tumour pathology has not been studied yet. Approach. The aim of this study was to investigate the dependence of the biological washout rate on tumour vascular status in rat irradiation. Two types of tumour vascularity conditions, perfused and hypoxic, were modelled with nude rats. The rats were irradiated by a radioactive 15O ion beam and time activity curves were acquired by dynamic in-beam PET measurement. Tumour tissue sections were obtained to observe the histology as well. The biological washout rate was derived using a single-compartment model with two decay components (medium decay, k2m and slow decay, k2s). Main results. All k2m values in the vascular perfused tumour tissue were higher than the values of the normal tissue. All k2m values in the hypoxic tumour tissue were much lower than the values of the vascular perfused tumour tissue and slightly lower than the values of the normal tissue. Significance. The dependency of the biological washout on the tumour vasculature conditions was experimentally shown. |
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| 書誌情報 |
Physics in Medicine & Biology 巻 67, p. 125006, 発行日 2022-05 |
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| 出版者 | ||||||
| 出版者 | IOP Publishing | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0031-9155 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1088/1361-6560/ac72f3 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://iopscience.iop.org/article/10.1088/1361-6560/ac72f3 | |||||
