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細胞死制御剤による粒子線防護効果のマウス個体レベルでの検討 Evaluation of cell death regulatory agents for protecting particle beam-irradiated mice
https://repo.qst.go.jp/records/86227
https://repo.qst.go.jp/records/86227d5bbe5cd-aa0c-4f21-b39c-2dfcf1bbcb36
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-05-20 | |||||
| タイトル | ||||||
| タイトル | 細胞死制御剤による粒子線防護効果のマウス個体レベルでの検討 Evaluation of cell death regulatory agents for protecting particle beam-irradiated mice | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
森田明典
× 森田明典× Bing, Wang× Kaoru, Tanaka× Takanori, Katsube× Masahiro, Murakami× Takashi, Shimokawa× 西山祐一× Bing, Wang× Kaoru, Tanaka× Takanori, Katsube× Masahiro, Murakami× Takashi, Shimokawa |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Recent studies have shown that p53 functions as a resistance factor that prevents cell death in radiation enteritis. We have identified 5-chloro-8-quinolinol (5CHQ) as an effective "p53 modulator" in intestinal death. In this study, we evaluated the activity of 5CHQ glycosides as prodrugs that enhance uptake by radiosensitive proliferative cells in order to develop p53 modulators with higher radioprotective activity than 5CHQ. A 5CHQ glycoside showed greater radioprotective activity than 5CHQ. Furthermore, the radioprotective effect of the 5CHQ glycoside was not observed in Trp53-knockout mice, indicating that the radioprotective effect of this compound is p53-dependent. In this year's study, the efficacy of the 5CHQ glycoside was evaluated using carbon beam (14 keV/µm) as an index of 80-day survival of individual mice. The 5CHQ glycoside-treated group showed a higher survival rate than the vehicle-treated group, but the protective effect was not statistically significant. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2021年度HIMAC共同利用研究成果報告会 | |||||
| 発表年月日 | ||||||
| 日付 | 2022-05-30 | |||||
| 日付タイプ | Issued | |||||
