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Revisiting the concept of peptide bond planarity in an iron-sulfur protein by neutron structure analysis
https://repo.qst.go.jp/records/86139
https://repo.qst.go.jp/records/86139e6b14f25-63c0-4268-bede-419f18402bcd
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-05-11 | |||||
| タイトル | ||||||
| タイトル | Revisiting the concept of peptide bond planarity in an iron-sulfur protein by neutron structure analysis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yuya, Hanazono
× Yuya, Hanazono× Yuu, Hirano× Kazuki, Takeda× Katsuhiro, Kusaka× Taro, Tamada× Kunio, Miki× Yuya, Hanazono× Yuu, Hirano× Taro, Tamada |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The planarity of the peptide bond is important for the stability and structure formation of proteins. However, substantial distortion of peptide bonds has been reported in several high-resolution structures and computational analyses. To investigate the peptide bond planarity, including hydrogen atoms, we report a 1.2 Å resolution neutron structure of the oxidized form of high-potential iron-sulfur protein. This high-resolution neutron structure shows that the nucleus positions of the amide protons deviate from the peptide plane and shift toward the acceptors. The planarity of the H-N-C=O plane depends strongly on the pyramidalization of the nitrogen atom. Moreover, the orientation of the amide proton of Cys75 is different in the reduced and oxidized states possibly due to the electron storage capacity of the iron-sulfur cluster. | |||||
| 書誌情報 |
Science Advances 巻 8, 号 20, p. 2276, 発行日 2022-05 |
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| 出版者 | ||||||
| 出版者 | American Association for the Advancement of Science | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2375-2548 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1126/sciadv.abn2276 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.science.org/doi/10.1126/sciadv.abn2276 | |||||
