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A Near-Infrared Organic Fluorescent Probe for Broad Applications for Blood Vessels Imaging by High-Throughput Screening via 3D-Blood Vessel Models
https://repo.qst.go.jp/records/85431
https://repo.qst.go.jp/records/854318fc27be0-ae4f-45f3-ad4a-b888619944f4
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-10-06 | |||||
| タイトル | ||||||
| タイトル | A Near-Infrared Organic Fluorescent Probe for Broad Applications for Blood Vessels Imaging by High-Throughput Screening via 3D-Blood Vessel Models | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Asri Abdul Sisak, Muhammad
× Asri Abdul Sisak, Muhammad× Louis, Fiona× Ichio, Aoki× Hyeok Lee, Sun× Young-Tae, Chang× Matsusaki, Michiya× Ichio, Aoki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Blood vessels are present in all of the organs, reflecting their importance for oxygen and nutrient delivery to the cells. Until now, no organic fluorophore has been reported for the live imaging of endothelium although the layer is the key to blood vessel functions. Here, the discovery of a blood vessel organic probe at near-infrared (NIR) wavelength range (BV-NIR) through an engineered blood capillary-based screening system, which is a more physiological model than a conventional cell culture condition, is reported. This selected Cy5 based probe shows the highest specific adsorption property out of 240 candidates on the endothelium and is equivalent to an anti-CD31 antibody in terms of intensity. The BV-NIR probe indicating strong and stable in vitro, ex vivo, and in vivo imaging of the endothelium even after histological immunostaining processes shows potential as a convenient tool for live imaging as well as for covisualization with a specific antibody. | |||||
| 書誌情報 |
Small Methods 巻 5, 号 8, p. 2170036, 発行日 2021-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2366-9608 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/smtd.202100338 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://onlinelibrary.wiley.com/doi/abs/10.1002/smtd.202100338 | |||||
