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High-sulfated hyaluronic acid ameliorates radiation-induced intestinal damage without blood anticoagulation
https://repo.qst.go.jp/records/85344
https://repo.qst.go.jp/records/853444c8c6351-eac6-4b24-8959-e03ca951e0dd
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-02-23 | |||||
| タイトル | ||||||
| タイトル | High-sulfated hyaluronic acid ameliorates radiation-induced intestinal damage without blood anticoagulation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Taichi, Miura
× Taichi, Miura× Mitsuko, Kawano× Keiko, Takahashi× Yuasa, Noriyuki× Habu, Masato× Kimura, Fumie× Toru, Imamura× Fumiaki, Nakayama× Taichi, Miura× Mitsuko, Kawano× Keiko, Takahashi× Toru, Imamura× Fumiaki, Nakayama |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: Many growth factors, such as fibroblast growth factors (FGFs), are useful for the treatment or prevention of radiation damage after radiotherapy. Although heparin can be supplemented to increase the therapeutic effects of FGFs, it possesses strong anticoagulant effects, which limit its potential for clinical use. Therefore, chemically-sulfated hyaluronic acid (HA) was developed as a safe alternative to heparin. This study examined the involvement of sulfated HA in the radioprotective and anticoagulant effects. Methods and Materials: FGF1 was administered intraperitoneally to BALB/c mice with sulfated HA 24 h before or after total body irradiation (TBI) with γ-rays. Several radioprotective effects were examined in the jejunum. The blood coagulation time in the presence of sulfated HA was measured using murine whole blood. Results: FGF1 with high-sulfated HA (HA-HS) exhibited almost the same level of in vitro mitogenic activity as heparin, whereas FGF1 with HA or low-sulfated HA (HA-LS) exhibited almost no mitogenic activity. Furthermore, HA-HS had high binding capability with FGF1. FGF1 with HA-HS significantly promoted crypt survival to the same level as heparin after TBI and reduced radiation-induced apoptosis in crypt cells. Moreover, pre-treatment of HA-HS without FGF1 also increased crypt survival and reduced apoptosis. Crypt survival with FGF1 in the presence of HA depended on the extent of sulfation of HA. Moreover, the blood anticoagulant effects of sulfated HA were weaker than those of heparin. As sulfated HA did not promote the reactivity of antithrombin III (AT-III) to thrombin, it did not increase anti-coagulative effects to the same extent as heparin. Conclusion: This study suggested that HA-HS promotes the radioprotective effects of FGF1 without anticoagulant effects. HA-HS has great potential for practical use to promote tissue regeneration after radiation damage. |
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| 書誌情報 |
Advances in Radiation Oncology 巻 7, 号 3, p. 100900, 発行日 2022-03 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2452-1094 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.adro.2022.100900 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.advancesradonc.org/article/S2452-1094(22)00007-0/fulltext | |||||
