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Silicon 3D Microdosimeters for Advanced Quality Assurance in Particle Therapy
https://repo.qst.go.jp/records/85235
https://repo.qst.go.jp/records/85235268ae4c6-0160-4dcd-85e5-26bfa514ec1a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-03-14 | |||||
| タイトル | ||||||
| タイトル | Silicon 3D Microdosimeters for Advanced Quality Assurance in Particle Therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
T. Tran, Linh
× T. Tran, Linh× James, Benjamin× Pan, Vladimir× Vohradsky, James× Peracchi, Stefania× Chartier, Lachlan× Debrot, Emily× Guatelli, Susana× Petasecca, Marco× Lerch, Michael× Prokopovich, Dale× Željko, Pastuović× Povoli, Marco× Kok, Angela× Taku, Inaniwa× Sung-Hyun, Lee× Naruhiro, Matsufuji× B. Rosenfeld, Anatoly× Taku, Inaniwa× Sung-Hyun, Lee× Naruhiro, Matsufuji |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The Centre for Medical Radiation Physics introduced the concept of Silicon On Insulator (SOI) microdosimeters with 3-Dimensional (3D) cylindrical sensitive volumes (SVs) mimicking the dimensions of cells in an array. Several designs of high-definition 3D SVs fabricated using 3D MEMS technology were implemented. 3D SVs were fabricated in different sizes and configurations with diameters between 18 and 30 µm, thicknesses of 2–50 µm and at a pitch of 50 µm in matrices with volumes of 20 × 20 and 50 × 50. SVs were segmented into sub-arrays to reduce capacitance and avoid pile up in high-dose rate pencil beam scanning applications. Detailed TCAD simulations and charge collection studies in individual SVs have been performed. The microdosimetry probe (MicroPlus) is composed of the silicon microdosimeter and low-noise front–end readout electronics housed in a PMMA waterproof sheath that allows measurements of lineal energies as low as 0.4 keV/µm in water or PMMA. Microdosimetric quantities measured with SOI microdosimeters and the MicroPlus probe were used to evaluate the relative biological effectiveness (RBE) of heavy ions and protons delivered by pencil-beam scanning and passive scattering systems in different particle therapy centres. The 3D detectors and MicroPlus probe developed for microdosimetry have the potential to provide confidence in the delivery of RBE optimized particle therapy when introduced into routine clinical practice | |||||
| 書誌情報 |
Applied Sciences 巻 12, 号 1, 発行日 2022-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2076-3417 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/app12010328 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.mdpi.com/2076-3417/12/1/328 | |||||
