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Cyclotron production of 225Ac from an electroplated 226Ra target
https://repo.qst.go.jp/records/85196
https://repo.qst.go.jp/records/85196d660d2a7-6b6e-4b6a-bf84-637e77ca9dd1
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-07-02 | |||||
| タイトル | ||||||
| タイトル | Cyclotron production of 225Ac from an electroplated 226Ra target | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kotaro, Nagatsu
× Kotaro, Nagatsu× Hisashi, Suzuki× Masami, Fukada× Taku, Ito× Jun, Ichinose× Yoshio, Honda× Katsuyuki, Minegishi× Tatsuya, Higashi× Zhang, Ming-Rong× Kotaro, Nagatsu× Hisashi, Suzuki× Masami, Fukada× Taku, Ito× Jun, Ichinose× Yoshio, Honda× Katsuyuki, Minegishi× Tatsuya, Higashi× Zhang, Ming-Rong |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose We demonstrate cyclotron production of high-quality 225Ac using an electroplated 226Ra target. Methods 226Ra was extracted from legacy Ra sources using a chelating resin. Subsequent ion-exchange purification gave pure 226Ra with a certain amount of carrier Ba. The radium target was prepared by electroplating. We successfully deposited about 37 MBq of 226Ra on a target box. Maximum activation was achieved using 15.6 MeV protons on the target at 20 µA for 5 h. Two functional resins with various concentrations of nitric acid purified 225Ac and recovered 226Ra. Cooling the intermediate 225Ac for 2–3 weeks decayed the major byproduct of 226Ac and increased the radionuclidic purity of 225Ac. Repeating the same separation protocol provided high-quality 225Ac. Results We obtained 225Ac at a yield of about 2.4 MBq at the end of bombardment (EOB), and the subsequent initial purification gave 1.7 MBq of 225Ac with 226Ac/225Ac ratio of < 3% at 4 days from EOB. Additional cooling time coupled with the separation procedure (secondary purification) effectively increased the 225Ac (4n + 1 series) radionuclidic purity up to 99 + %. The recovered 225Ac had a similar identification to commercially available 225Ac originating from a 229Th/225Ac generator. Conclusion This procedure, which involves the 226Ra(p,2n)225Ac reaction and the appropriate purification, has the potential to be a major alternative pathway for 225Ac production because it can be performed in any facility with a compact cyclotron to address the increasing demand for 225Ac. |
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| 書誌情報 |
European Journal of Nuclear Medicine and Molecular Imaging 巻 49, p. 279-289, 発行日 2021-06 |
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| 出版者 | ||||||
| 出版者 | SPRINGER | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1619-7070 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s00259-021-05460-7 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://link.springer.com/article/10.1007/s00259-021-05460-7 | |||||
