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A "Weird" Mitochondrial Fatty Acid Oxidation as a Metabolic "Secret" of Cancer.
https://repo.qst.go.jp/records/85008
https://repo.qst.go.jp/records/85008253ee096-7f4b-4177-8167-8ed5434b73e6
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-02-24 | |||||
| タイトル | ||||||
| タイトル | A "Weird" Mitochondrial Fatty Acid Oxidation as a Metabolic "Secret" of Cancer. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Zhelev, Zhivko
× Zhelev, Zhivko× Aoki, Ichio× Lazarova, Dessislava× Vlaykova, Tatyana× Bakalova, Rumiana× Higashi, Tatsuya× Ichio, Aoki× Bakalova, Rumiana× Tatsuya, Higashi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cancer metabolism is an extensively studied field since the discovery of the Warburg effect about 100 years ago and continues to be increasingly intriguing and enigmatic so far. It has become clear that glycolysis is not the only abnormally activated metabolic pathway in the cancer cells, but the same is true for the fatty acid synthesis (FAS) and mevalonate pathway. In the last decade, a lot of data have been accumulated on the pronounced mitochondrial fatty acid oxidation (mFAO) in many types of cancer cells. In this article, we discuss how mFAO can escape normal regulation under certain conditions and be overactivated. Such abnormal activation of mitochondrial -oxidation can also be combined with mutations in certain enzymes of the Krebs cycle that are common in cancer. If overactivated -oxidation is combined with other common cancer conditions, such as dysfunctions in the electron transport complexes, and/or hypoxia, this may alter the redox state of the mitochondrial matrix. We propose the idea that the altered mitochondrial redox state and/or inhibited Krebs cycle at certain segments may link mitochondrial -oxidation to the citrate-malate shuttle instead to the Krebs cycle. We call this abnormal metabolic condition "-oxidation shuttle". It is unconventional mFAO, a separate metabolic pathway, unexplored so far as a source of energy, as well as a source of cataplerosis, leading to biomass accumulation, accelerated oxygen consumption, and ultimately a source of proliferation. It is inefficient as an energy source and must consume significantly more oxygen per mole of ATP produced when combined with acetyl-CoA consuming pathways, such as the FAS and mevalonate pathway. | |||||
| 書誌情報 |
Oxidative medicine and cellular longevity 巻 2022, p. 2339584, 発行日 2022-05 |
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| 出版者 | ||||||
| 出版者 | Hindawi Pub. Corp. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1942-0994 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 35178152 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1155/2022/2339584 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1155/2022/2339584 | |||||
