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Extended ensemble simulations of a SARS-CoV-2 nsp1–5’-UTR complex
https://repo.qst.go.jp/records/84902
https://repo.qst.go.jp/records/84902acb6887c-2f70-4bea-80ff-8436ae35d0e2
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-01-29 | |||||
| タイトル | ||||||
| タイトル | Extended ensemble simulations of a SARS-CoV-2 nsp1–5’-UTR complex | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sakuraba, Shun
× Sakuraba, Shun× Xie, Qilin× Kasahara, Kota× Iwakiri, Junichi× Kono, Hidetoshi× Shun, Sakuraba× Hidetoshi, Kono |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Non-structural protein 1 (nsp1) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a 180-residue protein which blocks the translation of SARS-CoV-2 infected cells. Although it has been known that SARS-CoV-2's own RNA evades nsp1's host translation shutoff, its molecular mechanism has been poorly understood. We performed an extended ensemble molecular dynamics simulation to investigate the mechanism of the viral RNA evasion. Simulation results showed that the stem loop structure of SARS-CoV-2 RNA 5'-untranslated region is recognized by both nsp1's globular region and intrinsically disordered region. | |||||
| 書誌情報 |
PLoS Computational Biology 巻 18, 号 1, p. e1009804, 発行日 2022-02 |
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| 出版者 | ||||||
| 出版者 | PLoS | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1553-7358 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1371/journal.pcbi.1009804 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009804 | |||||
