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Inhibition of transient receptor potential vanilloid type 1 through α2 adrenergic receptors at peripheral nerve terminals relieves pain
https://repo.qst.go.jp/records/84803
https://repo.qst.go.jp/records/84803ca5a5c91-e21e-4532-80ce-fcd6f8250454
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-12-24 | |||||
| タイトル | ||||||
| タイトル | Inhibition of transient receptor potential vanilloid type 1 through α2 adrenergic receptors at peripheral nerve terminals relieves pain | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsushita, Yumi
× Matsushita, Yumi× Manabe, Miki× Kitagawa, Issei× Higuchi, Masashi× Z Hosaka, Yoshinao× Kitamura, Naoki× Yumi, Matsushita |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The activation of α adrenergic receptors contributes to analgesia not only in the central nervous system but also in the peripheral nervous system. We reported that noradrenaline inhibits the activity of transient receptor potential vanilloid 1 (TRPV1) evoked by capsaicin through α receptors in cultured rat dorsal root ganglion (DRG) neurons. However, it is unclear whether activation of TRPV1 expressed in peripheral nerve terminals is inhibited by α receptors and whether this phenomenon contributes to analgesia. Therefore, we examined effects of clonidine, an α receptor agonist, on several types of nociceptive behaviors, which may be caused by TRPV1 activity, and subtypes of α receptors expressed with TRPV1 in primary sensory neurons in rats. Capsaicin injected into hind paws evoked nociceptive behaviors and clonidine preinjected into the same site inhibited capsaicin-evoked responses. This inhibition was not observed when clonidine was injected into the contralateral hind paws. Preinjection of clonidine into the plantar surface of ipsilateral, but not contralateral, hind paws reduced the sensitivity to heat stimuli. Clonidine partially reduced formalin-evoked responses when it was preinjected into ipsilateral hind paws. The expression level of α receptor mRNA quantified by real-time PCR was highest followed by those of α and α receptors in DRGs. α and α receptor-like immunoreactivities were detected with TRPV1-like immunoreactivities in the same neurons. These results suggest that TRPV1 and α receptors are coexpressed in peripheral nerve terminals and that the functional association between these two molecules causes analgesia. | |||||
| 書誌情報 |
The Journal of veterinary medical science 巻 83, 号 10, p. 1570-1581, 発行日 2021-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0916-7250 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 34470979 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1292/jvms.21-0429 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/jvms/83/10/83_21-0429/_article/-char/en | |||||
