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Performance Evaluation for Repair of Hsgc-c5 Carcinoma Cell Using geant4-Dna
https://repo.qst.go.jp/records/84800
https://repo.qst.go.jp/records/8480066499fe7-a47a-4e84-9d05-8be9ec9f60a7
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-09-08 | |||||
| タイトル | ||||||
| タイトル | Performance Evaluation for Repair of Hsgc-c5 Carcinoma Cell Using geant4-Dna | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Dousatsu, Sakata
× Dousatsu, Sakata× Masao, Suzuki× Ryoichi, Hirayama× Yasushi, Abe× Masayuki, Muramatsu× Shinji, Sato× Belov, Oleg× Kyriakou, Ioanna× Emfietzoglou, Dimitris× Guatelli, Susanna× Incerti, Sebastien× Taku, Inaniwa× Dousatsu, Sakata× Masao, Suzuki× Ryoichi, Hirayama× Yasushi, Abe× Masayuki, Muramatsu× Shinji, Sato× Taku, Inaniwa |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Track-structure Monte Carlo simulations are useful tools to evaluate initial DNA damage induced by irradiation. In the previous study, we have developed a Gean4-DNA-based application to estimate the cell surviving fraction of V79 cells after irradiation, bridging the gap between the initial DNA damage and the DNA-rejoining kinetics by means of the two-lesion kinetics (TLK) model. However, since the DNA repair performance depends on cell line, the same model parameters cannot be used for the different cell lines. Thus, we extended the Geant4-DNA application with an updated TLK model for the evaluation of DNA damage repair performance in HSGc-C5 carcinoma cells which are typically used for evaluating proton/carbon radiation treatment effects. For this evaluation, we also performed experimental measurements for cell surviving fractions and DNA-rejoining kinetics of the HSGc-C5s cells. Concerning fast- and slow-DNA rejoining, the TLK model parameters were adequately optimized with the simulated initial DNA damage. Using the optimized TLK model, the Geant4-DNA simulation is now able to predict cell survival and DNA-rejoining kinetics for HSGc-C5s cells. | |||||
| 書誌情報 |
Cancers 巻 13, 号 23, p. 6046, 発行日 2021-12 |
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| 出版者 | ||||||
| 出版者 | MDPI | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2072-6694 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/cancers13236046 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.mdpi.com/2072-6694/13/23/6046 | |||||
